From: Clinical efficacy of adalimumab in Crohn’s disease: a real practice observational study in Japan
Remission (n = 41) | Non-remission (n = 21) | P value | |
---|---|---|---|
Age (years) | 32.1 ± 10.5 | 34.9 ± 10.1 | 0.3201a |
Gender (male) | 75.6 % (31/41) | 71.4 % (15/21) | 0.7648c |
Disease duration (months) | 87.0 (0.0–480.0) | 144.0 (0.0–336.0) | 0.3964b |
Disease duration < 2 years | 36.6 % (15/41) | 23.8 % (5/21) | 0.3962c |
Colonic type | 4.9 % (2/41) | 23.8 (5/21) | *0.0387c |
Surgery | 61.0 % (25/41) | 66.7 % (14/21) | 0.7837c |
Extra fistula | 30.0 % (12/40) | 42.9 % (9/21) | 0.3980c |
Intra fistula | 7.5 % (3/40) | 9.5 % (2/21) | >0.9999c |
Perianal disease | 46.3 % (19/41) | 52.4 % (11/21) | 0.7895c |
Smoking | 17.6 % (6/34) | 16.7 % (3/18) | >0.9999c |
Concomitant use | |||
5-Aminosalicylates | 87.8 % (36/41) | 100 % (21/21) | 0.1569c |
Steroids | 9.8 % (4/41) | 9.5 % (2/21) | >0.9999c |
Immunomodulators | 22.0 % (9/41) | 28.6 % (6/21) | 0.7548c |
Elemental diet | 65.9 % (27/41) | 57.1 % (12/21) | 0.5829c |
IFX experience | |||
Experience with IFX | 51.2 % (21/41) | 57.1 % (12/21) | 0.7895c |
Double dose | 28.6 % (6/21) | 41.7 % (5/12) | 0.4713c |
Duration of IFX use (months) | 19.5 (1.0–84.0) | 10.0 (1.0–100) | 0.7818b |
Reason of switch | 0.5700d | ||
PNR | 10.0 % (2/20) | 0.0 % (0/12) | |
SNR | 45.0 % (9/20) | 50.0 % (6/12) | |
Intolerance | 40.0 % (8/20) | 50.0 % (6/12) | |
Other | 5.0 % (1/20) | 0.0 % (0/12) | |
CDAI at baseline (points) | 169.5 ± 76.8 | 215.4 ± 67.2 | *0.0236a |
CRP at baseline (mg/dL) | 0.70 (0.00–6.86) | 0.88 (0.02–6.34) | 0.4436b |