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Table 2 Comparison of remission and non-remission groups at 52 weeks

From: Clinical efficacy of adalimumab in Crohn’s disease: a real practice observational study in Japan

 

Remission (n = 41)

Non-remission (n = 21)

P value

Age (years)

32.1 ± 10.5

34.9 ± 10.1

0.3201a

Gender (male)

75.6 % (31/41)

71.4 % (15/21)

0.7648c

Disease duration (months)

87.0 (0.0–480.0)

144.0 (0.0–336.0)

0.3964b

Disease duration < 2 years

36.6 % (15/41)

23.8 % (5/21)

0.3962c

Colonic type

4.9 % (2/41)

23.8 (5/21)

*0.0387c

Surgery

61.0 % (25/41)

66.7 % (14/21)

0.7837c

Extra fistula

30.0 % (12/40)

42.9 % (9/21)

0.3980c

Intra fistula

7.5 % (3/40)

9.5 % (2/21)

>0.9999c

Perianal disease

46.3 % (19/41)

52.4 % (11/21)

0.7895c

Smoking

17.6 % (6/34)

16.7 % (3/18)

>0.9999c

Concomitant use

   

 5-Aminosalicylates

87.8 % (36/41)

100 % (21/21)

0.1569c

 Steroids

9.8 % (4/41)

9.5 % (2/21)

>0.9999c

 Immunomodulators

22.0 % (9/41)

28.6 % (6/21)

0.7548c

 Elemental diet

65.9 % (27/41)

57.1 % (12/21)

0.5829c

IFX experience

   

 Experience with IFX

51.2 % (21/41)

57.1 % (12/21)

0.7895c

 Double dose

28.6 % (6/21)

41.7 % (5/12)

0.4713c

 Duration of IFX use (months)

19.5 (1.0–84.0)

10.0 (1.0–100)

0.7818b

 Reason of switch

  

0.5700d

  PNR

10.0 % (2/20)

0.0 % (0/12)

 

  SNR

45.0 % (9/20)

50.0 % (6/12)

 

  Intolerance

40.0 % (8/20)

50.0 % (6/12)

 

  Other

5.0 % (1/20)

0.0 % (0/12)

 

CDAI at baseline (points)

169.5 ± 76.8

215.4 ± 67.2

*0.0236a

CRP at baseline (mg/dL)

0.70 (0.00–6.86)

0.88 (0.02–6.34)

0.4436b

  1. Parametric variables are shown as mean ± standard deviation or median (range)
  2. IFX infliximab, PNR primary nonresponse, SNR secondary nonresponse, CDAI Crohn’s Disease Activity Index, CRP C-reactive protein
  3. *P < 0.05
  4. aStudent’s t-test; bMann-Whitney U-test; cFisher’s exact test; dChi-square test