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Table 2 Modified Spigelman’s Score and Classification [26]

From: Efficacy and safety of eflornithine (CPP-1X)/sulindac combination therapy versus each as monotherapy in patients with familial adenomatous polyposis (FAP): design and rationale of a randomized, double-blind, Phase III trial

 

Score

 

Factor

1 Point

2 Points

3 Points

Total Score

Stage

Number of polyps

1–4

5–20

>20

0

0

Polyp size, mm

1–4

5–10

>10

1–4

1

Histology

Tubulous

Tubulovillous

Villous

5–6

2

Dysplasia

Low grade

—

High gradea

7–8

3

 

9–12

4

  1. aAssigned to any epithelium showing nuclear stratification all the way to the tops of the cells and loss of mucin production. It can encompass intraepithelial carcinoma if the cells are pleomorphic or even cribiformed but still all located above the basement membrane
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BMC Gastroenterology

ISSN: 1471-230X

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