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Table 2 Modified Spigelman’s Score and Classification [26]

From: Efficacy and safety of eflornithine (CPP-1X)/sulindac combination therapy versus each as monotherapy in patients with familial adenomatous polyposis (FAP): design and rationale of a randomized, double-blind, Phase III trial

Factor 1 Point 2 Points 3 Points Total Score Stage
Number of polyps 1–4 5–20 >20 0 0
Polyp size, mm 1–4 5–10 >10 1–4 1
Histology Tubulous Tubulovillous Villous 5–6 2
Dysplasia Low grade High gradea 7–8 3
  9–12 4
  1. aAssigned to any epithelium showing nuclear stratification all the way to the tops of the cells and loss of mucin production. It can encompass intraepithelial carcinoma if the cells are pleomorphic or even cribiformed but still all located above the basement membrane