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Fig. 7 | BMC Gastroenterology

Fig. 7

From: Poly(ADP-ribose) polymerase inhibition suppresses inflammation and promotes recovery from adrenal injury in a rat model of acute necrotizing pancreatitis

Fig. 7

Western blot analysis of PAR, NF-kB, TNF-α and ICAM-1 of different groups. a The effect of inhibition on PAR after 12 h in pancreatitis animals pretreated with 3-AB. b Quantitative representation of the effects of 3-AB on PAR (n = 3). c The NF-kBp65 nuclear translocation, TNF-α and ICAM-1 activation increased in ANP group. After administration of 3-AB, the activation of NF-kB, TNF-α and ICAM-1 was significantly attenuated in adrenal. d Quantitative representation of the effects of 3-AB on the activation of NF-kB, TNF-α and ICAM-1. TBP (TATA-box binding protein) is a loading control of nuclear protein in Western blot analysis. *P < 0.05 vs. CON group, # P < 0.05 vs. ANP group

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