Fig. 4

PARP inhibition reduced adrenal insufficiency (a) and neutrophil infiltration (b) after ANP (n = 5). Morphologic changes of rat adrenals in control (d), ANP 3 h (e), ANP 6 h (f), ANP 12 h (g), 3-AB-treated 12 h (h) rats are shown. No histological alterations were observed in the adrenal tissues from control rats (d). 3-AB significantly reduced the severity of the histological signs of adrenal injury (f). Comparison of the total histology score of adrenal (c). Figure is representative of at least 3 experiments performed on different experimental days. Bar = 50 μm. Original magnification: ×400. *P < 0.05 vs. CON group, ^# P < 0.05 vs. ANP group