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Table 2 Linkage between SIBO and PPI intake

From: Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage

Cut-off of SIBO History of PPI intake   SIBO (-) SIBO (+) p OR (95 % CIs) p between ORsa
  No Non-IBS 478 (81.0 %) 53 (43.1 %)    0.498
≥103 cfu/ml   IBS 112 (19.0 %) 70 (56.9 %) <0.0001 5.63 (3.73–8.51) 0.499
  Yes Non-IBS 102 (68.5 %) 12 (34.3 %)    
   IBS 47 (31.5 %) 23 (65.7 %) <0.0001 4.16 (1.91–9.06)  
  No Non-IBS 482 (79.9 %) 49 (44.5 %)    0.712
≥104 cfu/ml   IBS 121 (20.1 %) 61 (55.5 %) <0.0001 4.95 (3.24–7.59) 0.712
  Yes Non-IBS 104 (67.5 %) 10 (33.3 %)    
   IBS 50 (32.5 %) 20 (66.7 %) 0.001 4.16 (1.81–9.54)  
  No Non-IBS 497 (77.8 %) 34 (45.9 %)    0.892
≥105 cfu/ml   IBS 142 (22.2 %) 40 (54.1 %) <0.0001 4.12 (2.51–6.75) 0.892
  Yes Non-IBS 107 (65.6 %) 7 (33.3 %)    
   IBS 56 (34.3 %) 14 (66.7 %) 0.007 3.82 (1.46–10.01)  
  1. aby the Tarone’s and Breslow-Day tests respectively