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Table 2 Linkage between SIBO and PPI intake

From: Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage

Cut-off of SIBO

History of PPI intake

 

SIBO (-)

SIBO (+)

p

OR (95 % CIs)

p between ORsa

 

No

Non-IBS

478 (81.0 %)

53 (43.1 %)

  

0.498

≥103 cfu/ml

 

IBS

112 (19.0 %)

70 (56.9 %)

<0.0001

5.63 (3.73–8.51)

0.499

 

Yes

Non-IBS

102 (68.5 %)

12 (34.3 %)

   
  

IBS

47 (31.5 %)

23 (65.7 %)

<0.0001

4.16 (1.91–9.06)

 
 

No

Non-IBS

482 (79.9 %)

49 (44.5 %)

  

0.712

≥104 cfu/ml

 

IBS

121 (20.1 %)

61 (55.5 %)

<0.0001

4.95 (3.24–7.59)

0.712

 

Yes

Non-IBS

104 (67.5 %)

10 (33.3 %)

   
  

IBS

50 (32.5 %)

20 (66.7 %)

0.001

4.16 (1.81–9.54)

 
 

No

Non-IBS

497 (77.8 %)

34 (45.9 %)

  

0.892

≥105 cfu/ml

 

IBS

142 (22.2 %)

40 (54.1 %)

<0.0001

4.12 (2.51–6.75)

0.892

 

Yes

Non-IBS

107 (65.6 %)

7 (33.3 %)

   
  

IBS

56 (34.3 %)

14 (66.7 %)

0.007

3.82 (1.46–10.01)

 
  1. aby the Tarone’s and Breslow-Day tests respectively