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Table 1 Demographic characteristic of enrolled patients in the prospective cohort

From: Small intestinal bacterial overgrowth is associated with irritable bowel syndrome and is independent of proton pump inhibitor usage

  No SIBO (n = 739) SIBO (n = 158) p
Age (years, mean ± SD) 63.3 ± 17.0 69.7 ± 17.4 <0.0001
Age ≥60 years (n, %) 475 (64.3) 129 (81.6) <0.0001
BMI (kg/m2, mean ± SD) 26.5 ± 5.3 25.6 ± 5.4 0.071
BMI ≥22 kg/m2 (n, %) 637 (86.5) 128 (81.0) 0.064
Presence of IBS (n, %) 159 (21.5 %) 93 (58.9 %) <0.0001
Type of IBS (n, %)    
 Predominant-diarrhea 44 (6.0) 33 (20.9) <0.0001
 Predominant-constipation 28 (3.5) 8 (5.1) 0.382
 Mixed type 87 (11.8) 52 (32.9) <0.0001
Co-morbidities (n, %)    
 Type 2 diabetes mellitus 171 (23.1) 53 (33.5) 0.008
 Chronic heart failure 192 (26.0) 49 (31.0) 0.200
 Chronic obstructive pulmonary disease 74 (10.0) 16 (10.02) 1.000
 Chronic renal disease 20 (2.7) 8 (5.1) 0.131
 Solid tumor malignancy 67 (9.1) 11 (7.0) 0.441
History of drug intake (n, %)    
 PPIs 149 (20.2 %) 35 (22.2 %) 0.588
 Non-steroidal anti-inflammatory drugs 30 (4.1 %) 11 (7.0) 0.139
 Low-dose aspirin 139 (18.8) 34 (21.5) 0.438
 Acenocoumarone 63 (8.5 %) 15 (9.5) 0.644
 H2-blockers 15 (2.0) 2 (1.3) 0.751
 Antacids 23 (3.1) 8 (5.1) 0.230
Clinical reason for gastroscopy (n, %)    
 Dyspepsia 422 (57.1) 94 (59.5) 0.596
 Anemia 327 (44.2) 83 (52.5) 0.065
 Unknown fever 21 (2.8) 7 (4.4) 0.312
Endoscopic findings (n, %)    
 Gastritis 388 (52.5) 58 (36.7) <0.0001
 Duodenal ulcer 46 (6.2) 12 (7.6) 0.481
 Gastric ulcer 9 (1.2) 1 (0.6) 1.000