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Fig. 1 | BMC Gastroenterology

Fig. 1

From: BAT117213: Ileal bile acid transporter (IBAT) inhibition as a treatment for pruritus in primary biliary cirrhosis: study protocol for a randomised controlled trial

Fig. 1

Mechanism of IBAT (ASBT) inhibitor drug. GSK2330672 interrupts the enterohepatic circulation of bile acids by selectively inhibiting the IBAT protein located in the terminal ileum, thereby reducing the levels of bile acids in the systemic circulation. (Image reproduced with permission from [31]). IBAT, ileal bile acid transporter; ASBT, apical sodium-dependent bile acid transporter

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