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Table 3 Cox proportional hazard regression model analyses of whole cohort

From: Prognostic significance of expression of cysteine-rich 61 and cyclooxygenase-2 in gastric cancer

  Univariate Multivariatea Multivariateb
  HR (95 % CI) p HR (95 % CI) p HR (95 % CI) p
Gender   0.316   0.968   0.704
 Male 1   1   1  
 Female 0.7 (0.3–1.5)   1.1 (0.4–2.5)   0.8 (0.3–2.07)  
Histological grade   0.031   0.563   0.697
 Grade I-II 1   1   1  
 Grade III 2.2 (1.08–4.5)   1.2 (0.6–2.6)   1.2 (0.6–2.4)  
Cyr-61 expression   < 0.001   0.008   -
 Low 1   1    
 High 6.9 (2.6–18.04)   4.1 (1.5–11.6)    
COX-2 expression   < 0.001   0.039   -
 Low 1   1    
 High 5.6 (2.4–13.03)   2.9 (1.06–7. 8)    
Combined expression of Cyr-61 and COX-2   0.001   -   0.003
 Both low 1     1  
 One low 18.2 (2.3–142.7) 0.006    17.9 (2.2–143.3) 0.006
 Both high 34.8 (4.6–262.4) 0.001    31.8 (4.09–246.8) 0.001
  1. Abbreviation: HR hazard ratio, CI confidence interval; amultivariate Cox regression analysis including sex, histological grade, Cyr-61 expression and COX-2 expression; bmultivariate Cox regression analysis including sex, histological grade, and combined expression of Cyr-61 and COX-2