Table 3 Cox proportional hazard regression model analyses of whole cohort

Gender

0.316

0.968

0.704

 Male

1

1

1

 Female

0.7 (0.3–1.5)

1.1 (0.4–2.5)

0.8 (0.3–2.07)

Histological grade

0.031

0.563

0.697

 Grade I-II

1

1

1

 Grade III

2.2 (1.08–4.5)

1.2 (0.6–2.6)

1.2 (0.6–2.4)

Cyr-61 expression

< 0.001

0.008

-

 Low

1

1

 High

6.9 (2.6–18.04)

4.1 (1.5–11.6)

COX-2 expression

< 0.001

0.039

-

 Low

1

1

 High

5.6 (2.4–13.03)

2.9 (1.06–7. 8)

Combined expression of Cyr-61 and COX-2

0.001

-

0.003

 Both low

1

1

 One low

18.2 (2.3–142.7)

0.006

17.9 (2.2–143.3)

0.006

 Both high

34.8 (4.6–262.4)

0.001

31.8 (4.09–246.8)

0.001