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Table 4 Summary of computed tomography findings, rate of positive findings, tumor number, and tumor size from 12 to 24 weeks

From: Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

  Week MF HFCD MF + DEN HFCD + DEN
Mice with positive findings, n (%) 12 0 0 0 0
16 0 0 0 1/5 (20 %)
20 0 1/5 (20 %) 0 5/5 (100 %)
24 0 0 1/5 (20 %) 5/5 (100 %)
Tumor number 12 0 0 0 0
16 0 0 0 5
20 0 6 0 10.0 ± 5.4
24 0 0 1 8.8 ± 5.4
Tumor size (mm) 12     
16     0.6 ± 0.4
20   0.8 ± 0.2   1.6 ± 0.8
24    2.2 2.9 ± 2.8
  1. Data are shown as the mean ± standard deviation. Data in bold indicate a significant difference (p < 0.05) between the standard diet (MF) group and the other groups for each month. HFCD high-fat choline-deficient diet, DEN diethylnitrosamine