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Table 2 Insulin resistance calculated using the quantitative insulin sensitivity check index

From: Development of a novel mouse model of hepatocellular carcinoma with nonalcoholic steatohepatitis using a high-fat, choline-deficient diet and intraperitoneal injection of diethylnitrosamine

  4 W 8 W 12 W 16 W 20 W 24 W
MF N.D. 0.227 0.139 N.D. N.D. 0.413
0.064 N.D. 0.348 N.D. 0.445 0.12
N.D. 0.381 0.193 N.D. N.D. 0.249
N.D. N.D. 0.416 0.315 N.D. 0.777
N.D. N.D. 0.672 N.D. N.D. 0.083
HFCD N.D. 0.22 0.089 0.058 0.026 0.045
0.2002 0.206 0.047 0.034 0.026 0.025
0.3954 0.168 0.067 0.034 0.057 0.025
0.0705 N.D. 0.081 0.027 0.034 0.018
0.1384 N.D. 0.046 0.079 0.037 0.030
MF + DEN 1.047 N.D. 0.579 N.D. N.D. 0.2916
N.D. N.D. N.D. N.D. N.D. 0.116
N.D. 0.916 N.D. 0.642 N.D. 0.131
N.D. 0.916 N.D. N.D. N.D. 0.153
N.D. 0.159 N.D. 9.101 0.245 N.D.
HFCD + DEN 1.047 0.0808 0.016 0.072 0.033 0.026
N.D. 0.1167 0.031 0.054 0.063 0.020
0.1026 0.377 0.030 0.025 0.069 0.034
0.0826 0.315 0.048 0.314 0.201 0.031
0.172 0.173 0.036 0.022 0.055 0.037
  1. The quantitative insulin sensitivity check index = 1/log (fasting insulin) + log (fasting glucose). A value < 0.3 indicates insulin resistance; values from 0.348 to 0.430 are normal, and values ≥ 3.0 indicate high insulin sensitivity (type 1 diabetes mellitus). Index values < 0.3 (insulin resistance) are in bold. Each group contained five mice. W weeks, MF standard diet, HFCD high-fat choline-deficient diet, DEN diethylnitrosamine, N.D not determined