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Fig. 6 | BMC Gastroenterology

Fig. 6

From: c-Jun N-terminal kinase activation has a prognostic implication and is negatively associated with FOXO1 activation in gastric cancer

Fig. 6

Schematic diagram showing the potential mechanism of cancer cell proliferation and growth regulated by the JNK/FOXO1 pathway in gastric cancer. As depicted, JNK activation induces cancer cell proliferation and growth by suppressing the transcriptional activity of FOXO1. When JNK is activated by phosphorylation, FOXO1 is phosphorylated, leading to its nuclear export and inactivation

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