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Table 1 Characteristics of the randomized controlled trials of probiotics vs. placebo in irritable bowel syndrome

From: Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis

Study Country Recruitment Sample size/probiotic Probiotic Dosage (CFU/D) Duration of treatment (W) Outcome measure
Sinn et al. [30] Korea Single-centre 40/20 L. acidophilus-SDC 2012, 2013 4 × 109 4 Response (reduction scores)
Hong et al. [31] Korea Single-centre 70/36 Bifidobacterium bifidum BGN4; Bifidobacterium lactis AD011; Lactobacillus acidophilus AD031; and Lactobacillus casei IBS041 4 × 1010 8 Response (reduction scores)
Guglielmetti et al. [32] Germany Multi-centre 122/60 Bifidobacterium bifidum MIMBb75 109 4 Response (>50 % relief); Pain/bloating (a 7-point Likert scale)
QoL (SF-12)
Michail et al. [33] USA Single-centre 24/15 VSL #3 9 × 1010 8 Pain/bloating (GSRS)
QoL (QoL questionnaires)
Ringel et al. [34] USA Single-centre 33/17 L-NCFM and B-LBi07 2 × 1011 8 Response (relief of symptoms)
Dapoigny et al. [35] France Multi-centre 50/25 L. casei variety rhamnosus (LCR35) 6 × 108 4 Response (reduction scores)
Pain/bloating (VAS)
QoL (GIQLI)
Ducrotté et al. [36] India Multi-centre 214/108 L. plantarum 299v (DSM9843) 1010 4 Response (good and excellent overall efficacy)
Pain/bloating (VAS)
Cui et al. [37] China Single-centre 60/37 Bifidobacterium longum and Lactobacillus acidophilus 6 × 107 4 Pain/bloating (rating score)
Cha et al. [38] Korea Single-centre 50/25 Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophiles 1010 8 Response (relief of symptoms)
Pain/bloating (VAS)
QoL (a 5-point Likert scale)
Amirimani et al. [39] Iran Multi-centre 72/41 Lactobacillus reuteri (Biogaia®) 1011 4 Pain/bloating (questionnaire)
Begtrup et al. [40] Denmark Single-centre 131/67 Lactobacillus para- casei ssp paracasei F19, Lactobacillus acidophilusLa5 and Bifidobacterium Bb12 5 × 1010 24 Response (relief of symptoms)
Pain/bloating (GSRS)
QoL (HRQOL-questionnaire)
Ko et al. [41] Korea Single-centre 26/14 Probiotics mixture containing 7 species (Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophiles) 1010 8 Response (reduction scores)
Pain/bloating (VAS)
QoL (a 5-point Likert scale)
Roberts et al. [42] UK Single-centre 179/88 Bifidobacterium lactis, S. thermophilus and L. bulgaricus 2.5 × 1010 12 Response (relief of symptoms)
Pain/bloating (a 6-point Likert scale)
QoL (the Birmingham Symptom Score)
Yoon et al. [43] Korea Single-centre 49/25 Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Streptococcus thermophiles. 1010 4 Response (relief of symptoms)
Pain/bloating (a 10-point numerical scale)
Abbas et al. [44] Pakistan Single-centre 72/37 S. boulardii 3 × 109 6 Pain/Bloating (a 4-point numerical scale)
Lorenzo et al. [45] Spain Multi-centre 71/47 L. plantarum and P. acidilactici (I.31) 3 × 109--6 × 109 6 Response (relief of symptoms)
QoL (a standardized score ranging from 1–100)
Ludidi et al. [46] Netherlands Single-centre 40/21 Bifidobacterium lactis, Lactobacillus casei, Lactobacillus salivarius, Lactococcus lactis, Lactobacillus acidophilus, and Lactobacillus rhamnosus 5 × 109 6 Response (MMS)
Pain/bloating (a 5-point Likert scale)
Urgesi et al. [47] Italy Single-centre 52/26 Bacillus coagulans (Colinox®) 4.5 × 109 4 Response (a 4-point Likert scale)
Pain/bloating (VAS)
Rogha et al. [48] Iran Single-centre 56/23 Bacillus coagulans 4.5 × 108 12 Pain/bloating (a 7-point numeric scale)
Sisson et al. [49] UK Single-centre 186/124 Symprove containing four strains of bacteria: Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus acidophilus, and Enterococcus faecium 1010 12 Response (IBS-SSS)
Pain/bloating (IBS-SSS)
QoL (a 100-point numerical scale)
Wong et al. [50] Singapore Single-centre 42/20 VSL #3 4.5 × 1011 6 Pain/bloating (SBDQ)
  1. GSRS gastrointestinal symptom rating scale, VAS visual analogue scale, GIQLI gastrointestinal quality of life index, HRQOL questionnaire health-related quality of life questionnaire, MMS mean symptom composite score, IBS-SSS irritable bowel syndrome-symptom severity score, SBDQ standardized bowel disease questionnaire
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