Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis

Zhang, Yan; Li, Lixiang; Guo, Chuanguo; Mu, Dan; Feng, Bingcheng; Zuo, Xiuli; Li, Yanqing

doi:10.1186/s12876-016-0470-z

Table 1 Characteristics of the randomized controlled trials of probiotics vs. placebo in irritable bowel syndrome

From: Effects of probiotic type, dose and treatment duration on irritable bowel syndrome diagnosed by Rome III criteria: a meta-analysis

Study	Country	Recruitment	Sample size/probiotic	Probiotic	Dosage (CFU/D)	Duration of treatment (W)	Outcome measure
Sinn et al. [30]	Korea	Single-centre	40/20	L. acidophilus-SDC 2012, 2013	4 × 10⁹	4	Response (reduction scores)
Hong et al. [31]	Korea	Single-centre	70/36	Bifidobacterium bifidum BGN4; Bifidobacterium lactis AD011; Lactobacillus acidophilus AD031; and Lactobacillus casei IBS041	4 × 10¹⁰	8	Response (reduction scores)
Guglielmetti et al. [32]	Germany	Multi-centre	122/60	Bifidobacterium bifidum MIMBb75	10⁹	4	Response (>50 % relief); Pain/bloating (a 7-point Likert scale)
Guglielmetti et al. [32]	Germany	Multi-centre	122/60	Bifidobacterium bifidum MIMBb75	10⁹	4	QoL (SF-12)
Michail et al. [33]	USA	Single-centre	24/15	VSL #3	9 × 10¹⁰	8	Pain/bloating (GSRS)
Michail et al. [33]	USA	Single-centre	24/15	VSL #3	9 × 10¹⁰	8	QoL (QoL questionnaires)
Ringel et al. [34]	USA	Single-centre	33/17	L-NCFM and B-LBi07	2 × 10¹¹	8	Response (relief of symptoms)
Dapoigny et al. [35]	France	Multi-centre	50/25	L. casei variety rhamnosus (LCR35)	6 × 10⁸	4	Response (reduction scores)
							Pain/bloating (VAS)
							QoL (GIQLI)
Ducrotté et al. [36]	India	Multi-centre	214/108	L. plantarum 299v (DSM9843)	10¹⁰	4	Response (good and excellent overall efficacy)
Ducrotté et al. [36]	India	Multi-centre	214/108	L. plantarum 299v (DSM9843)	10¹⁰	4	Pain/bloating (VAS)
Cui et al. [37]	China	Single-centre	60/37	Bifidobacterium longum and Lactobacillus acidophilus	6 × 10⁷	4	Pain/bloating (rating score)
Cha et al. [38]	Korea	Single-centre	50/25	Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophiles	10¹⁰	8	Response (relief of symptoms)
							Pain/bloating (VAS)
							QoL (a 5-point Likert scale)
Amirimani et al. [39]	Iran	Multi-centre	72/41	Lactobacillus reuteri (Biogaia®)	10¹¹	4	Pain/bloating (questionnaire)
Begtrup et al. [40]	Denmark	Single-centre	131/67	Lactobacillus para- casei ssp paracasei F19, Lactobacillus acidophilusLa5 and Bifidobacterium Bb12	5 × 10¹⁰	24	Response (relief of symptoms)
							Pain/bloating (GSRS)
							QoL (HRQOL-questionnaire)
Ko et al. [41]	Korea	Single-centre	26/14	Probiotics mixture containing 7 species (Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium breve, Bifidobacterium lactis, Bifidobacterium longum, and Streptococcus thermophiles)	10¹⁰	8	Response (reduction scores)
							Pain/bloating (VAS)
							QoL (a 5-point Likert scale)
Roberts et al. [42]	UK	Single-centre	179/88	Bifidobacterium lactis, S. thermophilus and L. bulgaricus	2.5 × 10¹⁰	12	Response (relief of symptoms)
							Pain/bloating (a 6-point Likert scale)
							QoL (the Birmingham Symptom Score)
Yoon et al. [43]	Korea	Single-centre	49/25	Bifidobacterium bifidum, Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, and Streptococcus thermophiles.	10¹⁰	4	Response (relief of symptoms)
Yoon et al. [43]	Korea	Single-centre	49/25		10¹⁰	4	Pain/bloating (a 10-point numerical scale)
Abbas et al. [44]	Pakistan	Single-centre	72/37	S. boulardii	3 × 10⁹	6	Pain/Bloating (a 4-point numerical scale)
Lorenzo et al. [45]	Spain	Multi-centre	71/47	L. plantarum and P. acidilactici (I.31)	3 × 10⁹--6 × 10⁹	6	Response (relief of symptoms)
Lorenzo et al. [45]	Spain	Multi-centre	71/47	L. plantarum and P. acidilactici (I.31)	3 × 10⁹--6 × 10⁹	6	QoL (a standardized score ranging from 1–100)
Ludidi et al. [46]	Netherlands	Single-centre	40/21	Bifidobacterium lactis, Lactobacillus casei, Lactobacillus salivarius, Lactococcus lactis, Lactobacillus acidophilus, and Lactobacillus rhamnosus	5 × 10⁹	6	Response (MMS)
Ludidi et al. [46]	Netherlands	Single-centre	40/21		5 × 10⁹	6	Pain/bloating (a 5-point Likert scale)
Urgesi et al. [47]	Italy	Single-centre	52/26	Bacillus coagulans (Colinox®)	4.5 × 10⁹	4	Response (a 4-point Likert scale)
Urgesi et al. [47]	Italy	Single-centre	52/26	Bacillus coagulans (Colinox®)	4.5 × 10⁹	4	Pain/bloating (VAS)
Rogha et al. [48]	Iran	Single-centre	56/23	Bacillus coagulans	4.5 × 10⁸	12	Pain/bloating (a 7-point numeric scale)
Sisson et al. [49]	UK	Single-centre	186/124	Symprove containing four strains of bacteria: Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus acidophilus, and Enterococcus faecium	10¹⁰	12	Response (IBS-SSS)
							Pain/bloating (IBS-SSS)
							QoL (a 100-point numerical scale)
Wong et al. [50]	Singapore	Single-centre	42/20	VSL #3	4.5 × 10¹¹	6	Pain/bloating (SBDQ)

GSRS gastrointestinal symptom rating scale, VAS visual analogue scale, GIQLI gastrointestinal quality of life index, HRQOL questionnaire health-related quality of life questionnaire, MMS mean symptom composite score, IBS-SSS irritable bowel syndrome-symptom severity score, SBDQ standardized bowel disease questionnaire

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ISSN: 1471-230X

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