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Table 2 Individual study results included in the network meta-analysis

From: Comparison of the effectiveness of polyethylene glycol with and without electrolytes in constipation: a systematic review and network meta-analysis

Study Assessment timea Stools per week (number of patients) Low risk of bias
PEG + E PEG Placebo Lactulose Serotonin agonist Bulk forming
Awad RA 2010 [14] 30 days   4.1 (N = 23) 4.0 (N = 24)     Yes
Cleveland MV 2001 [19] 14 days   7.0 (N = 23) 3.6 (N = 23)     No
Di Palma JA 1999 [22] (AM high dose) 10 days   5.6 (N = 50) 3.2 (N = 50)     No
Di Palma JA 1999 [22] (AM low dose) 10 days   3.8 (N = 50) 3.2 (N = 50)     No
Di Palma JA 1999 [22] (LT high dose) 10 days   4.9 (N = 17) 4.1 (N = 17)     No
Di Palma JA 1999 [22] (LT low dose) 10 days   3.2 (N = 17) 4.1 (N = 17)     No
Di Palma JA 2000 [23] 14 days   4.5 (N = 80) 2.7 (N = 71)     No
Di Palma JA 2007A [24] 14 days   8.9 (N = 46) 5.6 (N = 46)     Yes
Di Palma JA 2007B [25] 14 days   7.9 (N = 202) 5.6 (N = 100)     No
Klauser AG 1995 [28] 6 weeks   11.0 (N = 8) 3.0 (N = 8)     No
Andorsky RI 1990 [12] (High dose) 14 days 13.4 (N = 16)   7.5 (N = 16)     No
Andorsky RI 1990 [12] (Low dose) 14 days 8.1 (N = 16)   6.1 (N = 16)     No
Chapman RW 2013 [16] 4 weeks 4.4 (N = 68)   3.1 (N = 71)     Yes
Corazziari E 1996 [20] 4 weeks 4.8 (N = 25)   2.8 (N = 23)     No
Freedman MD 1997 [27] 14 days 6.9 (N = 57)   6.5 (N = 57) 5.8 (N = 57)    No
Zangaglia R 2007 [31] 8 weeks 6.6 (N = 29)   3.7 (N = 28)     No
Chaussade S 2003 [17] (High dose) 2 weeks 6.6 (N = 69) 8.2 (N = 67)      No
Chaussade S 2003 [17] (Low dose) 2 weeks 6.9 (N = 65) 6.0 (N = 65)      No
Seinela L 2009 [29] 2 weeks 8.7 (N = 32) 9.5 (N = 30)      No
Bouhnik Y 2004 [15] 28 days   8.8 (N = 32)   7.8 (N = 33)    No
Di Palma JA 2007C [26] 28 days   10.4 (N = 118)    8.5 (N = 116)   No
Attar A 1999 [13] 4 weeks 9.1 (N = 60)    6.3 (N = 55)    No
Cinca R 2013 [18] 2 weeks 3.2 (N = 120)     2.2 (N = 116)   Yes
Wang H 2005 [30] 2 weeks 8.5 (N = 63)      5.7 (N = 63) No
  1. aAssessment time was 14 days after treatment initiated (if available) or at end of treatment
  2. AM Ambulatory healthy outpatients, LT Long term