Table 2 Individual study results included in the network meta-analysis
Study | Assessment timea | Stools per week (number of patients) | Low risk of bias | |||||
|---|---|---|---|---|---|---|---|---|
PEG + E | PEG | Placebo | Lactulose | Serotonin agonist | Bulk forming | |||
Awad RA 2010 [14] | 30 days | 4.1 (N = 23) | 4.0 (N = 24) | Yes | ||||
Cleveland MV 2001 [19] | 14 days | 7.0 (N = 23) | 3.6 (N = 23) | No | ||||
Di Palma JA 1999 [22] (AM high dose) | 10 days | 5.6 (N = 50) | 3.2 (N = 50) | No | ||||
Di Palma JA 1999 [22] (AM low dose) | 10 days | 3.8 (N = 50) | 3.2 (N = 50) | No | ||||
Di Palma JA 1999 [22] (LT high dose) | 10 days | 4.9 (N = 17) | 4.1 (N = 17) | No | ||||
Di Palma JA 1999 [22] (LT low dose) | 10 days | 3.2 (N = 17) | 4.1 (N = 17) | No | ||||
Di Palma JA 2000 [23] | 14 days | 4.5 (N = 80) | 2.7 (N = 71) | No | ||||
Di Palma JA 2007A [24] | 14 days | 8.9 (N = 46) | 5.6 (N = 46) | Yes | ||||
Di Palma JA 2007B [25] | 14 days | 7.9 (N = 202) | 5.6 (N = 100) | No | ||||
Klauser AG 1995 [28] | 6 weeks | 11.0 (N = 8) | 3.0 (N = 8) | No | ||||
Andorsky RI 1990 [12] (High dose) | 14 days | 13.4 (N = 16) | 7.5 (N = 16) | No | ||||
Andorsky RI 1990 [12] (Low dose) | 14 days | 8.1 (N = 16) | 6.1 (N = 16) | No | ||||
Chapman RW 2013 [16] | 4 weeks | 4.4 (N = 68) | 3.1 (N = 71) | Yes | ||||
Corazziari E 1996 [20] | 4 weeks | 4.8 (N = 25) | 2.8 (N = 23) | No | ||||
Freedman MD 1997 [27] | 14 days | 6.9 (N = 57) | 6.5 (N = 57) | 5.8 (N = 57) | No | |||
Zangaglia R 2007 [31] | 8 weeks | 6.6 (N = 29) | 3.7 (N = 28) | No | ||||
Chaussade S 2003 [17] (High dose) | 2 weeks | 6.6 (N = 69) | 8.2 (N = 67) | No | ||||
Chaussade S 2003 [17] (Low dose) | 2 weeks | 6.9 (N = 65) | 6.0 (N = 65) | No | ||||
Seinela L 2009 [29] | 2 weeks | 8.7 (N = 32) | 9.5 (N = 30) | No | ||||
Bouhnik Y 2004 [15] | 28 days | 8.8 (N = 32) | 7.8 (N = 33) | No | ||||
Di Palma JA 2007C [26] | 28 days | 10.4 (N = 118) | 8.5 (N = 116) | No | ||||
Attar A 1999 [13] | 4 weeks | 9.1 (N = 60) | 6.3 (N = 55) | No | ||||
Cinca R 2013 [18] | 2 weeks | 3.2 (N = 120) | 2.2 (N = 116) | Yes | ||||
Wang H 2005 [30] | 2 weeks | 8.5 (N = 63) | 5.7 (N = 63) | No | ||||