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Table 2 Comparison between children in group A (age at diagnosis of Inflammatory Bowel Disease between 5 and 10 years) and those in group B (age at diagnosis of Inflammatory Bowel Disease between 11 and 16 years): disease activity and location at presentation (A), biochemical parameters at disease presentation (B), disease course and outcomes (C)

From: Clinical course and outcomes of diagnosing Inflammatory Bowel Disease in children 10 years and under: retrospective cohort study from two tertiary centres in the United Kingdom and in Italy

Variables All Group A vs Group B Brita Group A vs Group B Itab Group A vs Group B
A. Disease activity and location at presentation
Disease activity
CDc (PCDAId)
Group A: mean ± SDe 38.75 ± 2.7 45 ± 3.3 31.3 ± 3.44
Group B:mean ± SD 30.76 ± 2.02 32.2 ± 2.26 29.6 ± 3.5
P 0.05 0.003 0.7
UCf (PUCAIg)
Group A: mean ± SD 47.2 ± 2.5 55.2 ± 2.2 41.2 ± 2.7
Group B: mean ± SD 41.4 ± 1.8 41.6 ± 2.5 39.8 ± 3.65
P 0.03 0.03 0.8
ORh 1.09 1.11 1.03
95 % CIi 1.02–1.1 1.03–1.2 1.01–1.08
Disease location
CD
P 0.3 for L1 0.6 for L1 0.3 for L1
0.05 for L2 0.04 for L2 0.7 for L2
0.4 for L3 0.5 for L3 0.7 for L3
UC
P 0.7 for E1–E2 0.8 for E1–E2 0.6 for E1–E2
0.8 for E3–E4 0.9 for E3–E4 0.9 for E3–E4
B. Biochemical parameters at disease presentation
WBCj (x10^3/mm3)
Group A: mean ± SD 10.1 ± 0.45 10.9 ± 0.7 9.4 ± 0.6
Group B: mean ± SD 8.81 ± 0.35 9.09 ± 0.5 8.5 ± 0.47
P 0.03 0.04 0.3
HCTk (%)
Group A: mean ± SD 33.7 ± 0.57 32.6 ± 0.6 34.8 ± 0.9
Group B: mean ± SD 35.8 ± 0.5 34.9 ± 0.7 36.7 ± 0.6
P 0.005 0.02 0.09
Platelet count (x10^3/mm3)
Group A: mean ± SD 487 ± 18.9 476 ± 21.3 497.5 ± 31.2
Group B: mean ± SD 393 ± 13.4 404 ± 18.6 382 ± 19.3
P 0.002 0.01 0.003
C. Disease course and outcomes
Early treatment with thiopurines (within 3 months of diagnosis)
Group A 58 20 38
Group B 46 17 29
P 0.05 0.7 0.006
OR 1.86 1.04 7.19
95 % CI 1.02–4.33 0.8–2.63 0.9–77.4
Relapses (per patient/per year of follow-up)
Group A: mean ± SD 1.4 ± 0.2 1.53 ± 1.24 1.03 ± 0.3
Group B: mean ± SD 0.85 ± 0.1 0.9 ± 0.7 0.7 ± 0.13
P 0.05 0.005 0.3
OR 1.2 1.5 1.2
95 % CI 1.01–1.65 0.8–4.45 0.74–2.64
Number of endoscopies (per patient/per year of follow-up)
Group A: mean ± SD 0.9 ± 0.05 0.9 ± 0.06 0.9 ± 0.09
Group B: mean ± SD 0.75 ± 0.05 0.8 ± 0.07 0.7 ± 0.08
P 0.04 0.2 0.05
OR 1.67 1.2 7.07
95 % CI 1.01–4.19 0.98–1.58 1.09–45.9
  1. a Brit British
  2. b Ita Italian
  3. c CD Crohn’s disease
  4. d PCDAI paediatric Crohn’s disease activity index
  5. e SD standard deviation
  6. f UC ulcerative colitis
  7. g PUCAI paediatric ulcerative colitis activity index
  8. h OR odds ratio
  9. i CI confidence interval
  10. j WBC white blood cells
  11. k HCT haematocrit