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Table 2 Morphological changes in the rat liver assessed by NAFLD activity score (NAS)

From: Comparative experimental investigation on the efficacy of mono- and multiprobiotic strains in non-alcoholic fatty liver disease prevention

Parameters Intact rats (n = 10) MSG-induced obesity (n = 10) B. animalis VKL (n = 10) B. animalis VKB (n = 10) L. casei IMVB-7280 (n = 10) Poliprobiotics (n = 10) Symbiter (n = 10)
Steatosis (0–3) 0.10 ± 0.1a 2.30 ± 0.21d 2.0 ± 0.25cd 1.70 ± 0.21cd 1.80 ± 0.20cd 1.30 ± 0.3bc 0.70 ± 0.15ab
Lobular inflammation (0–2) 0.0 ± 0.0a 1.0 ± 0.21b 0.60 ± 0.16ab 0.40 ± 0.16ab 0.40 ± 0.16ab 0.30 ± 0.15a 0.10 ± 0.1a
Ballooning degeneration (0–2) 0.0 ± 0.0a 0.20 ± 0.13a 0.10 ± 0.1a 0.10 ± 0.1a 0.10 ± 0.1a 0.0 ± 0.0a 0.0 ± 0.0a
Total NAS (0–8) 0.0 ± 0.0a 3.60 ± 0.4d 2.70 ± 0.36cd 2.2 ± 0.25c 2.30 ± 0.21c 1.60 ± 0.3bc 0.80 ± 0.2ab
Prevalence of NASH, % 30 10
  1. Data are presented as the M ± SEM. One-way ANOVA with post hoc Tukeys test for multiple comparisons were performed for data analysis. a, b, c, d Values at the same row with different superscript letters show significant differences at p < 0.05