Comparative experimental investigation on the efficacy of mono- and multiprobiotic strains in non-alcoholic fatty liver disease prevention

Table 2 Morphological changes in the rat liver assessed by NAFLD activity score (NAS)

Parameters	Intact rats (n = 10)	MSG-induced obesity (n = 10)	B. animalis VKL (n = 10)	B. animalis VKB (n = 10)	L. casei IMVB-7280 (n = 10)	Poliprobiotics (n = 10)	Symbiter (n = 10)
Steatosis (0–3)	0.10 ± 0.1^a	2.30 ± 0.21^d	2.0 ± 0.25^cd	1.70 ± 0.21^cd	1.80 ± 0.20^cd	1.30 ± 0.3^bc	0.70 ± 0.15^ab
Lobular inflammation (0–2)	0.0 ± 0.0^a	1.0 ± 0.21^b	0.60 ± 0.16^ab	0.40 ± 0.16^ab	0.40 ± 0.16^ab	0.30 ± 0.15^a	0.10 ± 0.1^a
Ballooning degeneration (0–2)	0.0 ± 0.0^a	0.20 ± 0.13^a	0.10 ± 0.1^a	0.10 ± 0.1^a	0.10 ± 0.1^a	0.0 ± 0.0^a	0.0 ± 0.0^a
Total NAS (0–8)	0.0 ± 0.0^a	3.60 ± 0.4^d	2.70 ± 0.36^cd	2.2 ± 0.25^c	2.30 ± 0.21^c	1.60 ± 0.3^bc	0.80 ± 0.2^ab
Prevalence of NASH, %	–	30	10	–	–	–	–

Data are presented as the M ± SEM. One-way ANOVA with post hoc Tukeys test for multiple comparisons were performed for data analysis. ^{a, b, c, d} Values at the same row with different superscript letters show significant differences at p < 0.05

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