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Table 4 Baseline clinical characteristics of HCV-infected F1, F2 and F3 patients

From: Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C

Characteristics SVR NR P value Statistics (univariate)
(n = 49) (n = 57) OR(95%CI)
Age mean ± SD (years) 50.2 ± 8.5 49.3 ± 7.9 -  
Gender distribution[n(%)]    -  
 Male 34(69.3) 34(59.6)   
 Female 15(30.6) 23(40.3)   
BMI, median (range), kg/m2 23 ± 12 23 ± 12 -  
No of injection,s median (range) 48(24) 24(62) 0.004 1.042 (1.013- 1.072)
Tolerability, [n(%)] 49(100) 43(75.4)
*Adjusted No of injections ,mean ± SEM 37.28 ± 1.74 35.14 ± 1.63 -  
Viral load median, IU/mL 432,210 738,902 -  
aAST median (range), μkat/L 1.66(4.23) 1.28(4.2) -  
bALT median (range), μkat/L 1.78(5.47) 2.091(5.62) -  
Albumin median (range), g/L 39 ± 20 39 ± 10 -  
Bilirubin median (range), μmol/L 15.39 ± 50.44 13.6 ± 25.6 -  
Hemoglobin median (range), g/dL 13 ± 5.6 13.8 ± 4.6 -  
Platelets median (range), 109/L 163(236) 170(207) -  
cTLC mean ± SD, 109/μL 6.5(1.7) 6.5(1.3) -  
Cholesterol mean ± SD, mmol/L 4.1 ± 0.86 4.2 ± 0.6 -  
Glucose median (range), mmol/L 5.27 ± 3.277 5.5 ± 3.1 -  
Insulin median (range), pmol/L 79.6 ± 113.2 63.5 ± 133.3 -  
dHOMA-IR median (range) 2.5 ± 5.71 2.16 ± 6.04 -  
eAFP median (range), ng/mL 3.5(29.5) 8(26.3) 0.024 0.563 (0.342- 0.928)
*Adjusted AFP, mean ± SE 3.5 ± 0.049 3.448 ± 0.045   
25-OH Vitamin D mean ± SD, ng/mL 27.3 ± 9.2 21.07 ± 10.1 0.002 1.068(1.024-1.115)
IL28B rs12979860 [n(%)]    Chi2 = 31.35 p < 0.001
 C/C 28(57.1) 6(10.5) <0.001 11.33(4.09-39.35)
 C/T 20(40.8) 35(62.4)   
T/T 1(2) 16(28.07)   
T allele carriers/ T allele non carriers 21/28 51/6 <0.001 0.088(0.032-0.244)
VDR rs2228570 [n(%)]    Chi2 = 8.554 p = 0.014
 A/A 9(18.3) 1(1.7) 0.018 12.6(1.53-103.4)
 A/G 18(36.7) 24(42.1)   
 G/G 22(44.8) 32(56.1)   
  1. a AST, aspartate aminotransferase; b ALT, alanine aminotransferase; c TLC, total leukocyte count; d HOMA-IR, homeostatic model of insulin resistance; e AFP, alfa feto protein; NR, non-responders; SVR, sustained virological responders; N, number of samples; OR, odds ratio; 95%CI Confidence Interval.; Chi-square test for genotype distribution; IL28B: interleukin 28 B
  2. *Calculated by general linear model with adjustment for tolerability