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Table 3 Rates of SVR in relationship to IL28B rs12979860 and vitamin D related genes polymorphisms

From: Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C

  SVR P value
IL28B rs12979860 C/C C/C C/T + T/T C/T + T/T  
CYP2R1 rs10741657 A allele carrier Non A carrier A allele carrier Non A carrier  
N(%) 29/33 (87.8 %) 27/37(72.9 %) 22/62(35.4 %) 13/68(19.1 %) <0.001
VDR rs2228570 A allele carrier Non A carrier A allele carrier Non A carrier  
N(%) 27/29(93 %) 29/41(70.7 %) 23/66(34.8 %) 12/64(18.7) <0.001
CYP2R1 & VDR A allele carrier Non A carrier A allele carrier Non A carrier  
N(%) 17(100 %) 15/23(65.2 %) 15/30(50 %) 6/35(17 %) <0.001
  1. The statistical analysis was performed using a chi-squared test for linear trend
  2. IL28B: Interleukin 28 B; SVR: sustained viral response; CYP2R1: cytochrome P-450 family 2, subfamily R; VDR: vitamin D receptor
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BMC Gastroenterology

ISSN: 1471-230X

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