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Table 2 Association analysis of genes polymorphisms with the response to antiviral treatment

From: Integrative role of vitamin D related and Interleukin-28B genes polymorphism in predicting treatment outcomes of Chronic Hepatitis C

Genotype/ Allele SVR NR P value OR(95%CI)
N = 91 N = 109
CYP2R1 rs10741657 [n(%)]    Chi2 = 5.38 p = 0.06
 A/A 7(7.7) 4(3.7)   
 A/G 44(48.4) 40(36.7)   
 G/G 40(44) 59.6))65 0.028 0.531(0.302-0.933)
A allele carriers/A allele non carriers 51/40 44/65 0.027 1.884(1.072-3.310)
VDR rs2228570 [n(%)]    Chi2 = 8.66 p = 0.013
 A/A 13(14.3) 4(3.7) 0.013 4.375(1.374-13.932)
 A/G 36(39.6) 39(35.8)   
 G/G 42(46.2) 66(60.6)   
A allele carriers/A allele non carriers 49/42 43/66 0.042 1.791(1.019-3.146)
VDR rs1544410 [n(%)]    n.s.
 C/C 30(33) 38(34.9)   
 C/T 39(42.9) 47(43.1)   
 T/T 22(24.9) 24(22)   
T allele carriers/ T allele non carriers 61/30 71/38   
OASL rs1169279 [n(%)]    Chi2 = 5.4 p = 0.06
 C/C 19(20.9) 39(55.8) 0.022 0.474(0.250-0.898)
 C/T 52(57.1) 49(45)   
 T/T 20(22) 21(19.3)   
T allele carriers/ T allele non carriers 72/19 70/39 0.013 2.26(1.182-4.318)
ADAR rs1127309 [n(%)]    n.s.
 C/C 30(33) 38(34.9)   
 C/T 39(42.9) 47(43.1)   
 T/T 22(24.2) 24(22)   
T allele carriers/ T allele non carriers 61/30 71/109   
  1. OR, odds ratio; 95%CI Confidence Interval; n.s., non-significant; SVR: sustained viral response; NR: non response; CYP2R1: cytochrome P-450 family 2, subfamily R; VDR: vitamin D receptor; OASL: oligoadenylate synthetases-like; ADAR: adenosine deaminases acting on RNA
  2. Chi-square test for genotype distribution