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Table 5 Results of univariate and multivariate: independent predictors of fatty liver with ALT elevation in females with MS

From: Influence of light alcohol consumption on lifestyle-related diseases: a predictor of fatty liver with liver enzyme elevation in Japanese females with metabolic syndrome

 

Univariate analysis

Multivariate analysis

 

FL with ALT elevation (+) (n = 253)

FL with ALT elevation (−) (n = 888)

P-value

OR

95 % CI

P-value

Age (≧50/< 50 years)

187/66

739/149

<0.01

1.003

0.677–1.484

NS

BMI (≧25/< 25 kg/m2)

199/54

469/419

<0.001

2.181

1.445–3.293

<0.001

WC (≧90/< 90 cm)

166/87

348/540

<0.001

1.853

1.280–2.684

<0.01

SBP (≧130/< 130 mmHg)

138/115

557/331

<0.05

0.756

0.543–1.053

NS

DBP (≧85/< 85 mmHg)

76/177

197/691

<0.05

1.604

1.120–2.298

<0.05

Hypertension (+/−)

209/44

728/160

NS

   

T-CHO (≧220/< 220 mg/dl)

103/150

340/548

NS

   

TG (≧150/< 150 mg/dl)

105/148

206/682

<0.001

2.202

1.562–3.105

<0.001

HDL (<50/≧ 50 mg/dl)

96/157

217/671

<0.001

1.362

0.955–1.942

NS

LDL (≧140/< 140 mg/dl)

118/135

365/523

NS

   

Dyslipidemia (+/−)

236/17

58/830

NS

   

UA (≧7.0/< 7.0 mg/dl)

24/229

23/865

<0.001

2.959

1.537–5.698

<0.01

FPG (≧100/< 100 mg/dl)

202/51

641/247

<0.05

   

HbA1c (≧6.5/< 6.5 % NGSP)

70/183

110/778

<0.001

   

IGT (+/−)

204/49

648/240

<0.05

1.692

1.143–2.506

<0.01

AST (≧31/< 31 IU/l)

140/113

21/867

<0.001

   

GGT (≧51/< 51 IU/l)

90/163

94/794

<0.001

   

V-type MS/S-type MS

82/171

88/800

<0.001

3.708

2.529–5.437

<0.001

Light drinker/Non-drinker

76/177

268/620

NS

0.988

0.699–1.396

NS

Past history of smoking (+/−)

31/222

72/816

NS

1.182

0.705–1.981

NS

  1. Significant is at the 5 % level
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, BMI body mass index, CI confidence interval, DBP diastolic blood pressure, FL fatty liver, FPG fasting plasma glucose, GGT gamma-glutamyl transpeptidase, HbA1c hemoglobin A1c, HDL high density lipoprotein, IGT impaired glucose tolerance, LDL low density lipoprotein, MS metabolic syndrome, NGSP National Glycohemoglobin Standardization Program, NS not significant, OR odds ratio, SBP systolic blood pressure, S-type subcutaneous-type, T-CHO total cholesterol, TG triglyceride, UA uric acid, V-type visceral type, WC waist circumference. Light drinkers were subjects who drank from more than zero to less than 20 g/day of alcohol. Non-drinkers were subjects who drank 12 drinks (one drink means less 10 g) or less per year of less than 10 g/drinking day. ALT elevation was defined as ALT level of >31 IU/l in this study