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Table 5 Results of univariate and multivariate: independent predictors of fatty liver with ALT elevation in females with MS

From: Influence of light alcohol consumption on lifestyle-related diseases: a predictor of fatty liver with liver enzyme elevation in Japanese females with metabolic syndrome

  Univariate analysis Multivariate analysis
  FL with ALT elevation (+) (n = 253) FL with ALT elevation (−) (n = 888) P-value OR 95 % CI P-value
Age (50/< 50 years) 187/66 739/149 <0.01 1.003 0.677–1.484 NS
BMI (25/< 25 kg/m2) 199/54 469/419 <0.001 2.181 1.445–3.293 <0.001
WC (90/< 90 cm) 166/87 348/540 <0.001 1.853 1.280–2.684 <0.01
SBP (130/< 130 mmHg) 138/115 557/331 <0.05 0.756 0.543–1.053 NS
DBP (85/< 85 mmHg) 76/177 197/691 <0.05 1.604 1.120–2.298 <0.05
Hypertension (+/−) 209/44 728/160 NS    
T-CHO (220/< 220 mg/dl) 103/150 340/548 NS    
TG (150/< 150 mg/dl) 105/148 206/682 <0.001 2.202 1.562–3.105 <0.001
HDL (<50/ 50 mg/dl) 96/157 217/671 <0.001 1.362 0.955–1.942 NS
LDL (140/< 140 mg/dl) 118/135 365/523 NS    
Dyslipidemia (+/−) 236/17 58/830 NS    
UA (7.0/< 7.0 mg/dl) 24/229 23/865 <0.001 2.959 1.537–5.698 <0.01
FPG (100/< 100 mg/dl) 202/51 641/247 <0.05    
HbA1c (6.5/< 6.5 % NGSP) 70/183 110/778 <0.001    
IGT (+/−) 204/49 648/240 <0.05 1.692 1.143–2.506 <0.01
AST (31/< 31 IU/l) 140/113 21/867 <0.001    
GGT (51/< 51 IU/l) 90/163 94/794 <0.001    
V-type MS/S-type MS 82/171 88/800 <0.001 3.708 2.529–5.437 <0.001
Light drinker/Non-drinker 76/177 268/620 NS 0.988 0.699–1.396 NS
Past history of smoking (+/−) 31/222 72/816 NS 1.182 0.705–1.981 NS
  1. Significant is at the 5 % level
  2. ALT alanine aminotransferase, AST aspartate aminotransferase, BMI body mass index, CI confidence interval, DBP diastolic blood pressure, FL fatty liver, FPG fasting plasma glucose, GGT gamma-glutamyl transpeptidase, HbA1c hemoglobin A1c, HDL high density lipoprotein, IGT impaired glucose tolerance, LDL low density lipoprotein, MS metabolic syndrome, NGSP National Glycohemoglobin Standardization Program, NS not significant, OR odds ratio, SBP systolic blood pressure, S-type subcutaneous-type, T-CHO total cholesterol, TG triglyceride, UA uric acid, V-type visceral type, WC waist circumference. Light drinkers were subjects who drank from more than zero to less than 20 g/day of alcohol. Non-drinkers were subjects who drank 12 drinks (one drink means less 10 g) or less per year of less than 10 g/drinking day. ALT elevation was defined as ALT level of >31 IU/l in this study