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Table 3 Results of meta-analysis comparing hepatocellular carcinoma with or without biliary tumor thrombus

From: Surgical outcomes of hepatocellular carcinoma with biliary tumor thrombus: a systematic review

Outcome of interest No. of studies No. of patients BTT Non-BTT OR/WMD 95 % CI P value HG P value
Clinicopathological characteristics       
 Male 12 317 5806 1.07 0.97, 1.43 0.67 0.69
 Age 9 256 3840 0.01 −1.01, 1.02 0.99 0.01
 Hepatitis B surface antigen 11 297 5150 1.33 0.99, 1.79 0.06 0.35
 Hepatitis C virus antibody 9 243 4274 0.72 0.37, 1.39 0.33 0.03
 Cirrhosis 6 158 3569 0.72 0.51, 1.00 0.05 0.11
 Tumor size 7 177 4028 −0.89 −2.63, 0.85 0.32 <0.001
 Multiple tumor 6 166 3662 1.85 0.76, 4.52 0.18 <0.001
 Tumor capsule absence 7 176 2305 1.26 0.63, 2.51 0.62 0.02
 Intrahepatic metastases 5 109 1710 1.47 0.93, 2.33 0.10 0.40
 Vscular invasion 12 293 5939 4.70 2.90, 7.60 <0.001 0.001
 Poor differentiation 8 227 4003 2.07 1.23, 3.49 0.006 0.05
Long-term outcomes       
 1-year overall survival 12 280 4739 0.48 0.31, 0.72 <0.001 0.02
 3-year overall survival 12 280 4739 0.45 0.29, 0.68 <0.001 0.007
 5-year overall survival 10 231 4021 0.31 0.21, 0.64 <0.001 0.02
  1. BTT biliary tumor thrombus, OR odds ratio, WMD weighted mean difference, CI confidence interval, HG heterogeneity