From: Surgical outcomes of hepatocellular carcinoma with biliary tumor thrombus: a systematic review
Outcome of interest | No. of studies | No. of patients BTT Non-BTT | OR/WMD | 95 % CI | P value | HG P value |
---|---|---|---|---|---|---|
Clinicopathological characteristics | ||||||
Male | 12 | 317 5806 | 1.07 | 0.97, 1.43 | 0.67 | 0.69 |
Age | 9 | 256 3840 | 0.01 | −1.01, 1.02 | 0.99 | 0.01 |
Hepatitis B surface antigen | 11 | 297 5150 | 1.33 | 0.99, 1.79 | 0.06 | 0.35 |
Hepatitis C virus antibody | 9 | 243 4274 | 0.72 | 0.37, 1.39 | 0.33 | 0.03 |
Cirrhosis | 6 | 158 3569 | 0.72 | 0.51, 1.00 | 0.05 | 0.11 |
Tumor size | 7 | 177 4028 | −0.89 | −2.63, 0.85 | 0.32 | <0.001 |
Multiple tumor | 6 | 166 3662 | 1.85 | 0.76, 4.52 | 0.18 | <0.001 |
Tumor capsule absence | 7 | 176 2305 | 1.26 | 0.63, 2.51 | 0.62 | 0.02 |
Intrahepatic metastases | 5 | 109 1710 | 1.47 | 0.93, 2.33 | 0.10 | 0.40 |
Vscular invasion | 12 | 293 5939 | 4.70 | 2.90, 7.60 | <0.001 | 0.001 |
Poor differentiation | 8 | 227 4003 | 2.07 | 1.23, 3.49 | 0.006 | 0.05 |
Long-term outcomes | ||||||
1-year overall survival | 12 | 280 4739 | 0.48 | 0.31, 0.72 | <0.001 | 0.02 |
3-year overall survival | 12 | 280 4739 | 0.45 | 0.29, 0.68 | <0.001 | 0.007 |
5-year overall survival | 10 | 231 4021 | 0.31 | 0.21, 0.64 | <0.001 | 0.02 |