Table 1 Differential diagnosis of the rare cystic lesion of the pancreas
From: Pancreatic hamartoma: a case report and literature review
Age | Gender | Region | Morphology | Contents of the cyst | Histological feature | |
|---|---|---|---|---|---|---|
Lymphoepithelial cyst 1)20)21) | 50s-60s | Male | Uni- or multilocular | Serous to cheesy/caseous-appearing depending on the degree of keratin formation. | Lined by well-differentiated stratified squamous epithelium. Surrounding dense lymphoid tissue. | |
Cyst wall and trabeculae are usually thin. | ||||||
Epidermoid cyst 1)22) | 20s-30s | Female | Tail | Uni- or multilocular | Serous to cheesy/casseous-appearing depending on the degree of keratin formation. | Lined by attenuated squamous cells. Exist with accessory spleens. |
High levels of CA 19-9 and/or CEA in the serum and in the cystic fluid. | ||||||
Dermoid cyst 1)23)24) | 20s-30s | Unknown | Similar to the teratoma | Cheesy or caseous, with keratinaceous and sebaceous secretions. | Skin appendages and sebaceous glands, hair follicles, etc. | |
Squamoid cyst 1)25)26) | Unknown | Unknown | Unilocular | Acidophilic acinar | Cystically dilated ducts lined by a squamous/transitional epithelium. | |
Basal are positive for p63. | ||||||
Superficial cells are positive for MUC1, MUC6 and involucrin. | ||||||
Serous cystadenoma 1)27) | 60s | M:F=1: 3 | Body and tail | Multi-cystic large mass (mean size: 6 cm) | Serous fluid | Cuboidal glycogen-rich epithelial cells positive for GLUT-1. |
Sponge-like appearance | Clear cytoplasm and well-defined cytoplasmic borders. Small, round nuclei with dense homogeneous chromatin. | |||||
Von Hippel-Lindau gene is detected in 40% cases. | ||||||
Lipoma 28)29)30) | Unknown | Unknown | Hypodensity (-30 to -120 HU) and homogeneity in enhanced CT | Mature adipose tissue, capsuled by thin collagen layer | No evidence of typical pancreatic tissue. | |
Hamartoma 1),3)-19) | 50s- 60s | M:F=1.4:1 | Head | Solid and cystic mass | Mature acini, ducts with architectural disarrangement surrounded by stromal fibrosis. | C34, CD117 or bcr-2 expression for the stromal fibrosis. |
Lack or decrease of islet cells. | S-100 protein expression for the ductal component. |