Significant weight loss |
Gastrointestinal bleeding |
Hematemesis |
Melena |
Dysphagia |
Intractable vomiting |
Palpable abdominal mass |
History of documented |
Peptic ulcer |
Gastric cancer |
Gastric surgery |
Symptoms compatible with irritable bowel syndrome |
Hepatobiliary tract disease |
Severe concomitant medical conditions |
Pregnant woman |
Continuous usage of NSAIDa in the preceding 1 month before entry to the study |