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Table 2 Univariate analysis for predictive factors influencing overall survival and disease-free survival after curative resection

From: Prognostic impact of immunohistochemical expression of CK7 and CK20 in curatively resected ampulla of Vater cancer

Variables N 5 years survival rate Overall survival 5 years survival rate Disease-free survival
Hazard ratio P value Hazard ratio P value
Sex
  Male 18 87.2 2.33 (0.45–12.05) 0.311 77.8 1.07 (0.28–3.99) 0.919
  Female 19 68.0 73.7
Age, years
   < 60 14 80.0 1.79 (0.34–9.21) 0.489 78.6 1.27 (0.32–5.09) 0.733
   ≥ 60 23 75.9 73.9
Subtype
  Intestinal 17 93.3 8.45 (0.99–71.61) 0.051 94.1 8.34 (1.04–66.88) 0.046
  Pancreaticobiliary 20 60.5 60.0
CK7 +/CK20 -
  No 19 93.3 9.74 (1.16–81.89) 0.036 89.5 4.31 (0.89–20.77) 0.069
  Yes 18 57.5 61.1
CDX2
  No 20 75.2 1.26 (0.28–5.68) 0.764 75.0 1.02 (0.28–3.81) 0.972
  Yes 16 79.3 75.0
T stage
  T1, T2 22 95.2 13.94 (1.66–117.03) 0.015 95.5 14.81 (1.85–118.92) 0.011
  T3, T4 15 45.4 46.7
Lymph node metastasis
  No 31 88.4 6.00 (1.30–27.58) 0.021 83.9 5.69 (1.52–21.30) 0.010
  Yes 6 33.3 33.3
Lymphovascular invasion
  No 31 85.1 5.89 (1.27–27.38) 0.024 83.9 6.06 (1.58–23.28) 0.009
  Yes 6 31.3 33.3
Perineural invasion
  No 30 84.0 4.83 (1.07–21.87) 0.041 83.3 4.88 (1.29–18.40) 0.019
  Yes 7 47.6 42.9
Size
   < 2 cm 14 83.1 1.92 (0.37–9.94) 0.436 85.7 2.34 (0.49–11.25) 0.290
   ≥ 2 cm 23 73.8 69.6
Differentiation
  Well/mod 31 86.0 8.18 (1.57–42.67) 0.013 87.1 12.29 (3.06–48.31) <0.001
  Poorly 6 0 16.7
Stage
  I and IIA 31 88.4 6.00 (1.30–27.58) 0.021 83.9 5.69 (1.52–21.30) 0.010
  IIB and III 6 33.3 33.3
Ca19-9 (U/ml)
   < 37 12 70.0 0.66 (0.13–3.28) 0.611 66.7 0.40 (0.09–1.81) 0.236
   ≥ 37 20 84.0 85.0
CEA (ng/ml)
   < 5 27 83.2 1.28 (0.14–11.54) 0.826 81.5 1.37 (0.16–11.74) 0.774
   ≥ 5 4 75.0 75.0
Pancreatic fistula
  No 21 77.2 0.88 (0.20–3.95) 0.872 71.4 0.59 (0.15–2.35) 0.453
  Yes 16 77.9 81.3
Adjuvant therapy
  No 20 90.0 3.67 (0.70–19.02) 0.122 90.0 5.11 (1.06–24.68) 0.042
  Yes 17 58.2 58.8
  1. CK7 Cytokeratin 7, CK20 Cytokeratin 20, CA19-9 Carbohydrate antigen 19–9, CEA Carcinoembryonic antigen