Table 3 Multivariable-adjusted associations between clinical risk factors and advanced neoplasia

Age group in years

<.001

50–54

1.0

0

55–59

1.39 (1.03–1.88)

.032

.33

60–66

1.59 (1.18–2.15)

.002

.47

>66

1.95 (1.38–2.76)

<.001

.67

Family History of CRC

.45

None

1.0

0

1 first-degree relative ≥ 60 years old

1.34 (0.92–1.95)

.13

.29

1 first-degree relative < 60 years old

0.74 (0.27–2.05)

.56

-.30

2 first-degree relatives

1.29 (0.30–5.58)

.73

.25

Sex

<.001

Female

1.0

0

Male

1.38^a (0.89–2.14)

.15

.32

Smoking history in pack-years

.011

None

1.0

0

<10

1.01 (0.77–1.33)

.94

.098

10–19

1.35 (0.92–1.92)

.12

.30

≥20

1.66 (1.21–2.28)

.002

.51

BMI in kg/m²

.006

<25

1.0

0

25–29

1.02^b (0.68–1.53)

.91

.022

≥30

1.60^c (1.06–2.40)

.024

.47

BMI-sex interaction

.61

Male, 25–29 kg/m2

1.88^d (1.33–2.64)

.33^f

.28^f

Male, ≥30 kg/m2

2.56^e (1.76–3.71)

.62^f

.15^f