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Table 3 Multivariable-adjusted associations between clinical risk factors and advanced neoplasia

From: Evaluation of a clinical risk index for advanced colorectal neoplasia among a North American population of screening age

  LR test Adjusted OR (95 % CI)   Adjusted β coefficient
P-value P-value
Age group in years <.001    
50–54   1.0   0
55–59   1.39 (1.03–1.88) .032 .33
60–66   1.59 (1.18–2.15) .002 .47
>66   1.95 (1.38–2.76) <.001 .67
Family History of CRC .45    
None   1.0   0
1 first-degree relative ≥ 60 years old   1.34 (0.92–1.95) .13 .29
1 first-degree relative < 60 years old   0.74 (0.27–2.05) .56 -.30
2 first-degree relatives   1.29 (0.30–5.58) .73 .25
Sex <.001    
Female   1.0   0
Male   1.38a (0.89–2.14) .15 .32
Smoking history in pack-years .011    
None   1.0   0
<10   1.01 (0.77–1.33) .94 .098
10–19   1.35 (0.92–1.92) .12 .30
≥20   1.66 (1.21–2.28) .002 .51
BMI in kg/m2 .006    
<25   1.0   0
25–29   1.02b (0.68–1.53) .91 .022
≥30   1.60c (1.06–2.40) .024 .47
BMI-sex interaction .61  
Male, 25–29 kg/m2   1.88d (1.33–2.64) .33f .28f
Male, ≥30 kg/m2   2.56e (1.76–3.71) .62f .15f
  1. BMI body mass index, CRC colorectal cancer, CI confidence interval, LR likelihood ratio, OR odds ratio
  2. a,b,c,d,eOdds ratio for overall sex-BMI effect: amale, <25 kg/m2; bfemale, 25–29 kg/m2; cfemale, ≥30 kg/m2; dmale, 25–30 kg/m2; emale ≥30 kg/m2
  3. fβ coefficient/P-value for sex-BMI multivariable interaction terms