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Table 1 Association between HER2 status and clinicopathological parameters

From: Association between HER2 status in gastric cancer and clinicopathological features: a retrospective study using whole-tissue sections

 

Overall

HER2 positive

HER2 negative

P value

HER2 (3+)

HER2 (2+)

HER2 (0, 1+)

P value

 

n = 124 (%)

13(10.5)

111 (89.5)

 

13(10.5)

10 (8.1)

101(81.4)

 

Age at diagnosis

  

0.803

   

0.590

≥60 years

82 (66.1)

9

73

 

9

8

65

 

<60 years

42 (33.9)

4

38

 

4

2

36

 

Gender

  

0.865

   

0.459

Male

64 (51.6)

7

57

 

7

7

50

 

Female

60 (48.4)

6

54

 

6

3

51

 

Tumor topography

  

0.720

   

0.709

Distal stomach

100(80.6)

10

90

 

10

9

81

 

Proximal stomach/GEJ

24 (19.4)

3

21

 

3

1

20

 

Histological subtype

  

0.048

   

0.009

Intestinal

61 (49.2)

11

50

 

11

9

41

 

Diffuse

21 (16.9)

0

21

 

0

0

21

 

Mixed

33 (26.6)

2

31

 

2

1

30

 

Unditermined

9 (7.3)

0

9

 

0

0

9

 

Histological grade

  

0.004

   

<0.001

Well

13 (10.5)

4

9

 

4

1

8

 

Moderately

45 (36.3)

7

38

 

7

8

30

 

Poorly

66 (53.2)

2

64

 

2

1

63

 

Lymphovascular invasion

  

0.031

   

0.060

Positive

94 (75.8)

13

81

 

13

6

75

 

Negative

30 (24.2)

0

30

 

0

4

26

 

Blood-vessel invasion

  

0.395

   

0.170

Positive

44 (35.5)

6

38

 

6

1

37

 

Negative

80 (64.5)

7

73

 

7

9

64

 

pT status

  

0.271

   

0.165

pT1

17 (13.7)

0

17

 

0

1

16

 

pT2

32 (25.8)

3

29

 

3

2

27

 

pT3

69 (55.6)

10

59

 

10

5

54

 

pT4

6 (4.9)

0

6

 

0

2

4

 

pN status

  

0.453

   

0.762

pN0

39 (31.5)

2

37

 

2

4

33

 

pN1

46 (37.1)

7

39

 

7

4

35

 

pN2

24 (19.3)

3

21

 

3

1

20

 

pN3

15 (12.1)

1

14

 

1

1

13

 

pM status

  

0.548

   

0.705

pM0

121(97.6)

13

108

 

13

10

98

 

pM1

3 (2.4)

0

3

 

0

0

3

 
  1. Bold numbers represent P values with statistical significance