Table 3 Select liver transcripts in WD versus CTL rats related to pro-inflammatory cytokine, acute-phase protein response, and macrophage infiltration

Select genes involved in IL-6 signaling

IL-6

IL-6R

29.55

30.89

1.05

0.80

gp130

26.04

23.44

−1.11

0.44

Jak1

34.9

34.1

−1.02

0.66

Jak2

1.87

1.81

−1.03

0.78

Jak3

2.02

2.78

1.37

0.034

Stat3

15.43

16.20

1.05

0.68

Socs3

2.49

3.44

1.38

0.47

Select genes involved in TNF-α signaling

TNF-α

0.02

0.03

1.56

0.38

Tnfrsf1b

3.91

2.88

−1.36

0.08

Traf2

6.96

7.06

1.01

0.81

Rela (p65)

10.56

10.64

1.01

0.89

Nfkbia (IkBa)

18.57

18.35

−1.01

0.90

Select genes involved in IL-1β signaling

IL-1β

1.99

2.93

1.47

0.013

IL-1R1

6.38

6.79

1.07

0.75

Traf6

1.45

1.30

−1.12

0.23

Mapk8 (JNK1)

2.24

1.98

−1.13

0.32

Mapk9 (JNK2)

18.27

19.25

1.05

0.52

Select genes encoding acute phase response proteins

Apcs

1048

862

−1.22

0.047

Apoh

3874

3401

−1.07

0.006

C2

51.0

47.0

−1.09

0.10

C9

517

614

1.19

0.10

Crp

not on RNA-seq readout

F2

1051

1060

1.01

0.86

Fth1

1817

1969

1.08

0.18

Hmox1

16.3

17.0

1.05

0.62

Hp

1299

1603

1.24

0.0002

Hpx

2667

3086

1.16

0.11

IL-1rn

13.7

11.5

−1.19

0.35

Lbp

538

350

−1.54

0.002

Mur2

432

392

−1.10

0.31

Pf4

2.48

5.04

2.03

0.0004

Plg

944

868

−1.08

0.11

Sod2

41.8

47.2

1.13

0.013

Select genes representative of macrophage markers

Cd68

12.69

12.94

1.02

0.86

Emr1 (F4/80)

4.33

4.89

1.13

0.32

Itgax (Cd11c)

0.27

0.42

1.53

0.044

Itgam (Cd11b)

0.37

0.37

−1.01

0.92