Skip to main content

Table 3 Select liver transcripts in WD versus CTL rats related to pro-inflammatory cytokine, acute-phase protein response, and macrophage infiltration

From: Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats

Transcript CTL RPKM mean WD RPKM mean WD/CTL Fold-change Nominal p-value
Select genes involved in IL-6 signaling
IL-6 not on RNA-seq readout
IL-6R 29.55 30.89 1.05 0.80
gp130 26.04 23.44 −1.11 0.44
Jak1 34.9 34.1 −1.02 0.66
Jak2 1.87 1.81 −1.03 0.78
Jak3 2.02 2.78 1.37 0.034
Stat3 15.43 16.20 1.05 0.68
Socs3 2.49 3.44 1.38 0.47
Select genes involved in TNF-α signaling
TNF-α 0.02 0.03 1.56 0.38
Tnfrsf1b 3.91 2.88 −1.36 0.08
Traf2 6.96 7.06 1.01 0.81
Rela (p65) 10.56 10.64 1.01 0.89
Nfkbia (IkBa) 18.57 18.35 −1.01 0.90
Select genes involved in IL-1β signaling
IL-1β 1.99 2.93 1.47 0.013
IL-1R1 6.38 6.79 1.07 0.75
Traf6 1.45 1.30 −1.12 0.23
Mapk8 (JNK1) 2.24 1.98 −1.13 0.32
Mapk9 (JNK2) 18.27 19.25 1.05 0.52
Select genes encoding acute phase response proteins
Apcs 1048 862 −1.22 0.047
Apoh 3874 3401 −1.07 0.006
C2 51.0 47.0 −1.09 0.10
C9 517 614 1.19 0.10
Crp not on RNA-seq readout
F2 1051 1060 1.01 0.86
Fth1 1817 1969 1.08 0.18
Hmox1 16.3 17.0 1.05 0.62
Hp 1299 1603 1.24 0.0002
Hpx 2667 3086 1.16 0.11
IL-1rn 13.7 11.5 −1.19 0.35
Lbp 538 350 −1.54 0.002
Mur2 432 392 −1.10 0.31
Pf4 2.48 5.04 2.03 0.0004
Plg 944 868 −1.08 0.11
Sod2 41.8 47.2 1.13 0.013
Select genes representative of macrophage markers
Cd68 12.69 12.94 1.02 0.86
Emr1 (F4/80) 4.33 4.89 1.13 0.32
Itgax (Cd11c) 0.27 0.42 1.53 0.044
Itgam (Cd11b) 0.37 0.37 −1.01 0.92
  1. Bold-faced transcript indicates that nominal p-values < 0.05