|
Top transcripts up-regulated with WD feeding (FDR < 0.05, > 2.0 fold-change)
|
|
Stearoyl-CoA desaturase (delta-9-desaturase) (Scd)
|
Involved in fatty acid biosynthesis, primarily the synthesis of oleic acid; linked to inhibition of CPT-1A and suppression of mitochondrial fatty acid oxidation
|
28.392
|
0.01
|
0.00004
|
|
PDZ and LIM domain 1 (Pdlim1)
|
Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton
|
2.741
|
0.006
|
0.00002
|
|
Cytochrome P450, family 2, subfamily C, polypeptide 18 (Cyp2c18)
|
This gene encodes a member of the cytochrome P450 superfamily of enzymes which are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
|
2.504
|
0.01
|
0.00003
|
|
Platelet factor 4 (Pf4)
|
Chemotactic molecule for neutrophil and monocyte attraction
|
2.031
|
0.04
|
0.0004
|
|
Top transcripts down-regulated with WD feeding (FDR < 0.05, < −2.0 fold-change)
|
|
Cytochrome P450, family 51, subfamily A, polypeptide 1 (Cyp51a1)
|
This gene encodes a member of the cytochrome P450 superfamily of enzymes which are monooxygenases that catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids
|
−8.426
|
0.0001
|
0.00000006
|
|
Transmembrane 7 superfamily member 2 (Tm7sf2)
|
Involved in the conversion of lanosterol to cholesterol
|
−8.381
|
0.007
|
0.00002
|
|
3-hydroxy-3-methylglutaryl-CoA synthase 1 (Hmgcs1)
|
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase
|
−6.824
|
0.005
|
0.00001
|
|
Methylsterol monooxygenase 1 (Msmo1)
|
The protein is localized to the endoplasmic reticulum membrane and is believed to function in cholesterol biosynthesis
|
−6.482
|
0.002
|
0.000002
|
|
Zinc finger protein 48 (Znf48)
|
May be involved in transcriptional regulation
|
−6.458
|
0.00006
|
0.00000001
|
|
Insulin induced gene 1 (Insig1)
|
Mediates feedback control of cholesterol synthesis
|
−4.711
|
0.03
|
0.0002
|
|
RUN and SH3 domain containing 1 (Rusc1)
|
Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK; may be involved in regulation of the NF-kappa-B pathway
|
−4.705
|
0.0001
|
0.00000008
|
|
Farnesyl diphosphate synthase (Fdps)
|
Involved in cholesterol synthesis
|
−4.275
|
0.0003
|
0.0000003
|
|
Fatty acid desaturase 1 (Fads1)
|
Component of a lipid metabolic pathway that catalyzes biosynthesis of unsaturated fatty acids polyunsaturated fatty acids
|
−3.735
|
0.004
|
0.000007
|
|
Proprotein convertase subtilisin/kexin type 9 (Pcsk9)
|
Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic low-density lipoprotein receptor
|
−3.558
|
0.0001
|
0.0003
|
|
Cysteine sulfinic acid decarboxylase (Csad)
|
Plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis
|
−3.023
|
0.049
|
0.0005
|
|
ATP citrate lyase (Acly)
|
ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues; has a central role in de novo lipid synthesis
|
−2.879
|
0.049
|
0.0006
|
|
Acyl-CoA synthetase short-chain family member 2 (Acss2)
|
Activates acetate so that it can be used for lipid synthesis or for energy generation
|
−2.426
|
0.0001
|
0.00000003
|
|
Lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) (Lss)
|
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus
|
−2.388
|
0.02
|
0.00008
|
|
Deoxyribonuclease II beta (Dnase2b)
|
Gene is ubiquitously expressed but liver function unknown
|
−2.344
|
0.02
|
0.0002
|
|
Phosphomevalonate kinase (Pmvk)
|
Involved in the cholesterol biosynthetic pathway
|
−2.278
|
0.004
|
0.000006
|
|
UDP glucuronosyltransferase 2 family, polypeptide A3 (Ugt2a3)
|
UDP-glucuronosyltransferases are involved in the elimination of potentially toxic xenobiotics and endogenous compounds
|
−2.129
|
0.009
|
0.00003
|
