Western diet-induced hepatic steatosis and alterations in the liver transcriptome in adult Brown-Norway rats

BMC Gastroenterology

Table 1 Animal characteristics following 6 weeks of WD versus CTL feeding

Variable	CTL	WD	p-value
Body and tissue masses
Body mass at sacrifice (g)	329 ± 7	350 ± 12	0.002
Omental fat mass (g)	0.25 ± 0.03	0.38 ± 0.03	<0.001
Perirenal fat mass (g)	1.70 ± 0.14	2.95 ± 0.40	<0.001
Dietary data
Total kcal consumed	2,488 ± 32	2,849 ± 38	<0.001
Total protein consumed (g)	100 ± 1	110 ± 1	<0.001
Total carbohydrate consumed (g)	461 ± 6	307 ± 4	<0.001
Total fat consumed (g)	40 ± 1	134 ± 2	<0.001
Total sucrose consumed (g)	8.5 ± 0.1	215 ± 3	<0.001
Total cholesterol consumed (g)	0.099 ± 0.001	1.27 ± 0.02	<0.001
Liver characteristics
Fat deposition (Oil-Red O area; AUs)	167.6 ± 51.3	701.3 ± 139.5	0.004
Liver TAGs (nmol/g tissue)	3.34 ± 0.25	7.53 ± 0.58	<0.001

Values are means ± SE. Body mass, total kcal consumed, and Oil-Red O data previously reported [10]; symbols: g, grams; AUs, arbitrary units

ISSN: 1471-230X