Fig. 2

WD feeding dysregulates hepatic cholesterol biosynthesis gene expression. Values are means ± SE for Panel a. Total serum cholesterol (a) tended to be higher in WD. and transcript levels of a number of cholesterol biosynthesis genes unaltered with WD feeding (b, all responses p < 0.05). Top Regulator Effector Network in IPA (c) involved in the regulation of cholesterol biosynthesis. Cyp51a1, cytochrome P450, family 51, subfamily A, polypeptide 1; Ebp, emopamil binding protein (sterol isomerase); Fdft1, farnesyl-diphosphate farnesyltransferase 1; Fdps, farnesyl diphosphate synthase; Hmgcs1, 3-hydroxy-3-methylglutaryl-CoA synthase 1; Lss, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Msmo1, methylsterol monooxygenase 1; Pmvk, phosphomevalonate kinase; Sc5d, sterol-C5-desaturase; Tm7sf2, transmembrane 7 superfamily member 2; Adrb, Beta Adrenergic Receptor; Atp7b, ATPase, Cu++ transporting, beta polypeptide; Insig1, insulin induced gene 1; Pex5l, peroxisomal biogenesis factor 5-like; Srebf2, sterol regulatory element binding factor 2