Fig. 1

The top regulated gene network in WD versus CTL rats. The top regulated gene network in WD versus CTL rats included ‘Lipid metabolism, small molecular biochemistry, vitamin and mineral metabolism’ (IPA score 61; Fig. 1). Specific hubs down-regulated (green) in WD were Srebp2, Insig1, and Cyp51a1. Scd is the only molecule in the shown network to be up-regulated. Molecules shown in the network are: Acly, ATP citrate lyase; Acss2, acyl-CoA synthetase short-chain family member 2; Adhfe1, alcohol dehydrogenase, iron containing, 1; Apoh, apolipoprotein H (beta-2-glycoprotein I); Cyp51a1, cytochrome P450, family 51, subfamily A, polypeptide 1; Ebp, emopamil binding protein (sterol isomerase); Fads1, fatty acid desaturase 1; Fdft1, farnesyl-diphosphate farnesyltransferase 1; Ghr, growth hormone receptor; Hmgcs1, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); Hp, haptoglobin; Hsd11b1, hydroxysteroid (11-beta) dehydrogenase 1; Insig1, insulin induced gene 1; Irf6, interferon regulatory factor 6; Lipc, hepatic lipase, hepatic; Lss, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Msmo1, methylsterol monooxygenase 1; Nucb2, nucleobindin 2; Pcsk9, proprotein convertase subtilisin/kexin type 9; Pmvk, phosphomevalonate kinase; Pon3, paraoxonase 3; Sc5d, sterol-C5-desaturase; Scd, stearoyl-CoA desaturase (delta-9-desaturase); Srebf2, sterol regulatory element binding transcription factor 2; Stard4, StAR-related lipid transfer (START) domain containing 4; Tm7sf2, transmembrane 7 superfamily member 2