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Fig. 4 | BMC Gastroenterology

Fig. 4

From: Combination of sorafenib and gadolinium chloride (GdCl3) attenuates dimethylnitrosamine(DMN)-induced liver fibrosis in rats

Fig. 4

Effects of sorafenib and/or GdCl3 on in vivo expression of pro-fibrotic factors in rat liver fibrosis. a α-SMA immunohistochemistry (magnification X 200, n = 4). b Levels of mRNA encoded by genes encoding factors associated with fibrosis sis (n = 6). c the Expression of α-SMA, TIMP1, TGF-β1, COL1 was analyzed using western blot (n = 6). Control, vehicle alone; 4 W, DMN for 4 weeks; S, DMN for 4 weeks plus sorafenib for 2 weeks; G, DMN for 4 weeks plus GdCl3 for 2 weeks; S + G, DMN for 4 weeks plus sorafenib and GdCl3 for 2 weeks. Results reported as mean ± S.D. * p < 0.05; ** p < 0.01 vs 4 W

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