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Table 4 Baseline characteristics among duloxetine and comparator propensity score-matched cohorts, ORD, 01 August 2004–30 September 2010

From: Hepatic outcomes among adults taking duloxetine: a retrospective cohort study in a US health care claims database

Baseline Characteristic Duloxetine-Venlafaxine Duloxetine-SSRI Duloxetine-Untreated
Duloxetine Venlafaxine Duloxetine SSRIs Duloxetine Untreated
(N = 21,000) (N = 21,000) (N = 28,479) (N = 28,479) (N = 22,714) (N = 22,714)
  N % N % N % N % N % N %
Age group (years)             
 18–25 1855 8.8 1807 8.6 2154 7.6 2057 7.2 1829 8.1 1812 8.0
 26–30 1748 8.3 1758 8.4 2070 7.3 1992 7.0 1746 7.7 1764 7.8
 31–35 2473 11.8 2487 11.8 3101 10.9 3128 11.0 2493 11.0 2501 11.0
 36–40 3067 14.6 2979 14.2 4034 14.2 4008 14.1 3160 13.9 3108 13.7
 41–50 6152 29.3 6218 29.6 8667 30.4 8733 30.7 6725 29.6 6703 29.5
 51–60 4371 20.8 4419 21.0 6390 22.4 6436 22.6 5041 22.2 5030 22.1
 61–70 1176 5.6 1175 5.6 1817 6.4 1871 6.6 1506 6.6 1582 7.0
  ≥ 71 158 0.8 157 0.7 246 0.9 254 0.9 214 0.9 214 0.9
Female 15,074 71.8 15,092 71.9 20,570 72.2 20,405 71.6 15,974 70.3 16,020 70.5
Number of unique ICD-9 codes             
 0–4 1924 9.2 1948 9.3 2291 8.0 2169 7.6 2019 8.9 1894 8.3
 5–8 4228 20.1 4208 20.0 5002 17.6 5006 17.6 4270 18.8 4145 18.2
 9–12 4603 21.9 4657 22.2 5893 20.7 6039 21.2 4874 21.5 4866 21.4
 13–16 3706 17.6 3704 17.6 5059 17.8 5086 17.9 4071 17.9 4092 18.0
 17+ 6539 31.1 6483 30.9 10,234 35.9 10,179 35.7 7480 32.9 7717 34.0
Number of different drugs dispensed             
 0–3 2525 12.0 2410 11.5 2656 9.3 2253 7.9 2640 11.6 2482 10.9
 4–7 6365 30.3 6427 30.6 7553 26.5 7654 26.9 6890 30.3 6873 30.3
 8+ 12,110 57.7 12,163 57.9 18,270 64.2 18,572 65.2 13,184 58.0 13,359 58.8
Total costs (mean std) 7944.9 14,910.5 7685.7 14,071.0 9354.0 16,773.2 9113.6 18,729.4 8295.0 15,748.1 8201.4 15,713.5
ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ ᅟ
Psychotic disorders 7746 36.9 7685 36.6 11,187 39.3 11,029 38.7 7345 32.3 7349 32.4
Fibromyalgia 1936 9.2 1858 8.8 3760 13.2 3625 12.7 2610 11.5 2620 11.5
Back pain 2974 14.2 2863 13.6 4916 17.3 4921 17.3 3658 16.1 3764 16.6
Bilirubin test 971 4.6 972 4.6 1364 4.8 1350 4.7 1042 4.6 1031 4.5
ALT/AST/ALP test 788 3.8 790 3.8 1205 4.2 1208 4.2 924 4.1 952 4.2
NSAID use (excluding diclofenac) 5643 26.9 5730 27.3 8573 30.1 8591 30.2 6534 28.8 6776 29.8
Use of other medications             
Diclofenac 736 3.5 710 3.4 1206 4.2 1203 4.2 900 4.0 920 4.1
Valproic acid 408 1.9 439 2.1 653 2.3 673 2.4 451 2.0 471 2.1
Nitrofurantoin 796 3.8 773 3.7 1146 4.0 1121 3.9 875 3.9 962 4.2
Fluconazole 1684 8.0 1701 8.1 2428 8.5 2417 8.5 1872 8.2 1974 8.7
Statins 3008 14.3 3002 14.3 4518 15.9 4666 16.4 3584 15.8 3609 15.9
Anticonvulsants 5403 25.7 5406 25.7 8817 31.0 8745 30.7 5799 25.5 5774 25.4
Anxiolytics or sedative hypnotics 10,192 48.5 10,072 48.0 14,698 51.6 14,701 51.6 10,673 47.0 10,724 47.2
Antihistamines 4364 20.8 4315 20.5 6230 21.9 6183 21.7 4699 20.7 4920 21.7
Antipsychotics 1689 8.0 1710 8.1 2549 9.0 2510 8.8 1455 6.4 1773 7.8
Narcotic analgesics 9533 45.4 9452 45.0 14,366 50.4 14,339 50.3 10,923 48.1 11,090 48.8
  1. ORD Optum Research Database, SSRI selective serotonin reuptake inhibitor, ALT alanine aminotransferase, AST aspartate aminotransferase, ALP alkaline phosphatase, NSAID nonsteroidal anti-inflammatory drug, ICD-9 International Classification of Diseases, 9th Edition, std standard deviation
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