Table 4 Baseline characteristics among duloxetine and comparator propensity score-matched cohorts, ORD, 01 August 2004–30 September 2010
Baseline Characteristic | Duloxetine-Venlafaxine | Duloxetine-SSRI | Duloxetine-Untreated | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Duloxetine | Venlafaxine | Duloxetine | SSRIs | Duloxetine | Untreated | |||||||
(N = 21,000) | (N = 21,000) | (N = 28,479) | (N = 28,479) | (N = 22,714) | (N = 22,714) | |||||||
N | % | N | % | N | % | N | % | N | % | N | % | |
Age group (years) | ||||||||||||
18–25 | 1855 | 8.8 | 1807 | 8.6 | 2154 | 7.6 | 2057 | 7.2 | 1829 | 8.1 | 1812 | 8.0 |
26–30 | 1748 | 8.3 | 1758 | 8.4 | 2070 | 7.3 | 1992 | 7.0 | 1746 | 7.7 | 1764 | 7.8 |
31–35 | 2473 | 11.8 | 2487 | 11.8 | 3101 | 10.9 | 3128 | 11.0 | 2493 | 11.0 | 2501 | 11.0 |
36–40 | 3067 | 14.6 | 2979 | 14.2 | 4034 | 14.2 | 4008 | 14.1 | 3160 | 13.9 | 3108 | 13.7 |
41–50 | 6152 | 29.3 | 6218 | 29.6 | 8667 | 30.4 | 8733 | 30.7 | 6725 | 29.6 | 6703 | 29.5 |
51–60 | 4371 | 20.8 | 4419 | 21.0 | 6390 | 22.4 | 6436 | 22.6 | 5041 | 22.2 | 5030 | 22.1 |
61–70 | 1176 | 5.6 | 1175 | 5.6 | 1817 | 6.4 | 1871 | 6.6 | 1506 | 6.6 | 1582 | 7.0 |
≥ 71 | 158 | 0.8 | 157 | 0.7 | 246 | 0.9 | 254 | 0.9 | 214 | 0.9 | 214 | 0.9 |
Female | 15,074 | 71.8 | 15,092 | 71.9 | 20,570 | 72.2 | 20,405 | 71.6 | 15,974 | 70.3 | 16,020 | 70.5 |
Number of unique ICD-9 codes | ||||||||||||
0–4 | 1924 | 9.2 | 1948 | 9.3 | 2291 | 8.0 | 2169 | 7.6 | 2019 | 8.9 | 1894 | 8.3 |
5–8 | 4228 | 20.1 | 4208 | 20.0 | 5002 | 17.6 | 5006 | 17.6 | 4270 | 18.8 | 4145 | 18.2 |
9–12 | 4603 | 21.9 | 4657 | 22.2 | 5893 | 20.7 | 6039 | 21.2 | 4874 | 21.5 | 4866 | 21.4 |
13–16 | 3706 | 17.6 | 3704 | 17.6 | 5059 | 17.8 | 5086 | 17.9 | 4071 | 17.9 | 4092 | 18.0 |
17+ | 6539 | 31.1 | 6483 | 30.9 | 10,234 | 35.9 | 10,179 | 35.7 | 7480 | 32.9 | 7717 | 34.0 |
Number of different drugs dispensed | ||||||||||||
0–3 | 2525 | 12.0 | 2410 | 11.5 | 2656 | 9.3 | 2253 | 7.9 | 2640 | 11.6 | 2482 | 10.9 |
4–7 | 6365 | 30.3 | 6427 | 30.6 | 7553 | 26.5 | 7654 | 26.9 | 6890 | 30.3 | 6873 | 30.3 |
8+ | 12,110 | 57.7 | 12,163 | 57.9 | 18,270 | 64.2 | 18,572 | 65.2 | 13,184 | 58.0 | 13,359 | 58.8 |
Total costs (mean std) | 7944.9 | 14,910.5 | 7685.7 | 14,071.0 | 9354.0 | 16,773.2 | 9113.6 | 18,729.4 | 8295.0 | 15,748.1 | 8201.4 | 15,713.5 |
ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ | ᅟ |
Psychotic disorders | 7746 | 36.9 | 7685 | 36.6 | 11,187 | 39.3 | 11,029 | 38.7 | 7345 | 32.3 | 7349 | 32.4 |
Fibromyalgia | 1936 | 9.2 | 1858 | 8.8 | 3760 | 13.2 | 3625 | 12.7 | 2610 | 11.5 | 2620 | 11.5 |
Back pain | 2974 | 14.2 | 2863 | 13.6 | 4916 | 17.3 | 4921 | 17.3 | 3658 | 16.1 | 3764 | 16.6 |
Bilirubin test | 971 | 4.6 | 972 | 4.6 | 1364 | 4.8 | 1350 | 4.7 | 1042 | 4.6 | 1031 | 4.5 |
ALT/AST/ALP test | 788 | 3.8 | 790 | 3.8 | 1205 | 4.2 | 1208 | 4.2 | 924 | 4.1 | 952 | 4.2 |
NSAID use (excluding diclofenac) | 5643 | 26.9 | 5730 | 27.3 | 8573 | 30.1 | 8591 | 30.2 | 6534 | 28.8 | 6776 | 29.8 |
Use of other medications | ||||||||||||
Diclofenac | 736 | 3.5 | 710 | 3.4 | 1206 | 4.2 | 1203 | 4.2 | 900 | 4.0 | 920 | 4.1 |
Valproic acid | 408 | 1.9 | 439 | 2.1 | 653 | 2.3 | 673 | 2.4 | 451 | 2.0 | 471 | 2.1 |
Nitrofurantoin | 796 | 3.8 | 773 | 3.7 | 1146 | 4.0 | 1121 | 3.9 | 875 | 3.9 | 962 | 4.2 |
Fluconazole | 1684 | 8.0 | 1701 | 8.1 | 2428 | 8.5 | 2417 | 8.5 | 1872 | 8.2 | 1974 | 8.7 |
Statins | 3008 | 14.3 | 3002 | 14.3 | 4518 | 15.9 | 4666 | 16.4 | 3584 | 15.8 | 3609 | 15.9 |
Anticonvulsants | 5403 | 25.7 | 5406 | 25.7 | 8817 | 31.0 | 8745 | 30.7 | 5799 | 25.5 | 5774 | 25.4 |
Anxiolytics or sedative hypnotics | 10,192 | 48.5 | 10,072 | 48.0 | 14,698 | 51.6 | 14,701 | 51.6 | 10,673 | 47.0 | 10,724 | 47.2 |
Antihistamines | 4364 | 20.8 | 4315 | 20.5 | 6230 | 21.9 | 6183 | 21.7 | 4699 | 20.7 | 4920 | 21.7 |
Antipsychotics | 1689 | 8.0 | 1710 | 8.1 | 2549 | 9.0 | 2510 | 8.8 | 1455 | 6.4 | 1773 | 7.8 |
Narcotic analgesics | 9533 | 45.4 | 9452 | 45.0 | 14,366 | 50.4 | 14,339 | 50.3 | 10,923 | 48.1 | 11,090 | 48.8 |