Skip to main content

Table 4 New treatment options for laxative-resistant chronic constipationá…ź

From: Chronic constipation in the elderly: a primer for the gastroenterologist

Drug Mechanism of action Effect Possible side effects
Lubiprostone Type 2 chloride channel (CCl2) activator. Chloride secretion in the intestinal lumen followed by passive diffusion of sodium and water. Nausea, headache.
Increase in faecal content of water with distension of intestinal walls and activation of peristalsis and acceleration of intestinal transit.
Linaclotide Plecanatide Guanylate cyclase C receptor agonist. Increase of intra and extra-cellular cyclic guanosine monophosphate. Dose-dependent diarrhea.
Increase of secretion of chloride, bicarbonate and water into intestinal lumen.
Activation of peristalsis and acceleration of intestinal transit.
Prucalopride 5-HT4 serotonin receptor agonist. Excitatory activity of neurons of the myenteric plexus. Headache, nausea, diarrhea.
Norcisapride Release of acetylcholine.
Velusetrag Activation of peristalsis and acceleration of intestinal transit.
Elobixibat Enantiomer of 1,5-benzothiazepine. Bond and inhibits the ileal bile acid transporter. Abdominal pain, diarrhea.
Increased stay of bile acid in the colon. Activation of peristalsis and acceleration of intestinal transit.
\