Table 4 Clinical features of HLA-DR4-positiveand HLA-DR4-negativeautoimmune hepatitis in young-to middle-aged patients (<55 years old)

HLA-DR4-positive AIH (n = 34)

HLA-DR4-negative AIH (n = 15)

P-value

Discrete traits

N (%)

N (%)

 Sex

1.000

  Male

5 (14.7)

2 (13.3)

  Female

29 (85.3)

13 (86.7)

 Pattern of disease onset Acute onset

17 (50.0)

7 (46.7)

1.000

 Other autoimmune diseases

7 (20.6)

4 (26.7)

0.717

 Death from liver disease-related causes

1 (2.9)

0 (0)

1.000

 ANA positivity

28 (82.4)

10 (66.7)

0.275

 ANA (<40/40/80/>80)

7/5/9/13

5/2/2/6

0.642

 AMA positivity

4 (11.8)

1 (6.7)

1.000

 Splenomegaly

6 (18.8)

10 (71.4)

0.002

 Fibrosis stage (F0-F2/F3-F4)

23/8

8/5

0.478

Continuous traits

Median (Min-Max)

Median (Min-Max)

P-value

 Age (years)

46.5 (15–54)

36 (9–54)

0.178

 Total bilirubin (mg/dL)

1.1 (0.4–30.4)

1.1 (0.6–18.6)

0.965

 Aspartate aminotransferase (U/L)

313.5 (21–2314)

213 (42–1536)

0.957

 Alanine aminotransferase (U/L)

499.5 (15–2207)

252 (39–2016)

0.983

 Alkaline phosphatase (U/L)

477 (245–732)

491 (184–1463)

0.357

 Gamma-glutamyl transpeptidase (IU/L)

181 (26–1404)

166 (23–679)

0.558

 Prothrombin time (%)

94 (29–130)

85 (47–130)

0.389

 Albumin (g/dL)

4.0 (2.2–4.7)

4.1 (2.9–4.7)

0.267

 Platelets (x 10⁴/pL)

21.65 (9.7–39.6)

18.0 (8.5–31.5)

0.175

 Immunoglobulin G (mg/dL)

2116.5 (938–6750)

2305 (945–4961)

0.374

 Immunoglobulin M (mg/dL)

179.5 (65–890)

231 (59–888)

0.428

 AIH score (except for histology score)

12 (6–16)

13 (8–17)

0.197

 AIH score (including histology score)

16 (9–21)

17 (9–22)

0.112