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Table 4 Clinical features of HLA-DR4-positiveand HLA-DR4-negativeautoimmune hepatitis in young-to middle-aged patients (<55 years old)

From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis

  HLA-DR4-positive AIH (n = 34) HLA-DR4-negative AIH (n = 15) P-value
Discrete traits N (%) N (%)  
 Sex    1.000
  Male 5 (14.7) 2 (13.3)
  Female 29 (85.3) 13 (86.7)
 Pattern of disease onset Acute onset 17 (50.0) 7 (46.7) 1.000
 Other autoimmune diseases 7 (20.6) 4 (26.7) 0.717
 Death from liver disease-related causes 1 (2.9) 0 (0) 1.000
 ANA positivity 28 (82.4) 10 (66.7) 0.275
 ANA (<40/40/80/>80) 7/5/9/13 5/2/2/6 0.642
 AMA positivity 4 (11.8) 1 (6.7) 1.000
Splenomegaly 6 (18.8) 10 (71.4) 0.002
 Fibrosis stage (F0-F2/F3-F4) 23/8 8/5 0.478
Continuous traits Median (Min-Max) Median (Min-Max) P-value
 Age (years) 46.5 (15–54) 36 (9–54) 0.178
 Total bilirubin (mg/dL) 1.1 (0.4–30.4) 1.1 (0.6–18.6) 0.965
 Aspartate aminotransferase (U/L) 313.5 (21–2314) 213 (42–1536) 0.957
 Alanine aminotransferase (U/L) 499.5 (15–2207) 252 (39–2016) 0.983
 Alkaline phosphatase (U/L) 477 (245–732) 491 (184–1463) 0.357
 Gamma-glutamyl transpeptidase (IU/L) 181 (26–1404) 166 (23–679) 0.558
 Prothrombin time (%) 94 (29–130) 85 (47–130) 0.389
 Albumin (g/dL) 4.0 (2.2–4.7) 4.1 (2.9–4.7) 0.267
 Platelets (x 104/pL) 21.65 (9.7–39.6) 18.0 (8.5–31.5) 0.175
 Immunoglobulin G (mg/dL) 2116.5 (938–6750) 2305 (945–4961) 0.374
 Immunoglobulin M (mg/dL) 179.5 (65–890) 231 (59–888) 0.428
 AIH score (except for histology score) 12 (6–16) 13 (8–17) 0.197
 AIH score (including histology score) 16 (9–21) 17 (9–22) 0.112
  1. Bold-faced type shows statistically significant difference