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Table 3 Clinical features of HLA-DR4-positiveand HLA-DR4-negativeautoimmune hepatitis in elderly patients (>65 years old)

From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis

  HLA-DR4-positive AlH (n = 22) HLA-DR4-negative AIH (n = 27) P-value
Discrete traits N (%) N (%)  
 Sex    0.084
  Male 3 (13.6) 0 (0)
  Female 19 (86.4) 27 (100)
 Pattern of disease onset Acute onset 4 (18.2) 11 (40.7) 0.123
 Other autoimmune diseases 4 (18.2) 2 (7.4) 0.388
 Death from liver disease-related causes 2 (9.10 3 (11.1) 1.000
 ANA positivity 22 (100) 24 (88.9) 0.242
 ANA (<40/40/80/<80) 0/1/6/15 3/5/6/13 0.065
 AMA positivity 5 (22.7) 2 (7.4) 0.219
 Splenomegaly 9 (40.9) 8 (30.8) 0.548
 Fibrosis stage (F0-F2/F3-F4) 6/11 16/7 0.053
Continuous traits Median (Min-Max) Median (Min-Max) P-value
 Age (years) 72 (65–86) 73 (66–88) 0.657
 Total bilirubin (mg/dL) 1.1 (0.5–19.0) 1.1 (0.5–33.2) 0.976
 Aspartate aminotransferase (U/L) 188 (58–1177) 290 (20–641) 0.376
 Alanine aminotransferase (U/L) 191 (62–1208) 284 (16–714) 0.330
 Alkaline phosphatase (U/L) 441.5 (239–1145) 443 (170–793) 0.802
 Gamma-glutamyl transpeptidase (IU/L) 130.5 (47–466) 203 (20–587) 0.287
 Prothrombin time (%) 80.5 (30–104.8) 82 (49–114.4) 0.481
 Albumin (g/dL) 3.5 (2.2–4.5) 3.8 (2.2–4.6) 0.190
 Platelets (x 104/pL) 14.85 (9.6–27.7) 15.7 (8.0–28.8) 0.920
Immunoglobulin G (mg/dL) 2724.5 (1758–5495) 2030 (1243–3157) <0.0001
Immunoglobulin M (mg/dL) 215 (62–1330) 98 (47–396) 0.003
 AIH score (except for histology score) 14 (7–17) 13 (7–16) 0.053
AIH score (including histology score) 19 (12–22) 17 (8–21) 0.037
  1. Bold-faced type shows statistically significant difference