Table 3 Clinical features of HLA-DR4-positiveand HLA-DR4-negativeautoimmune hepatitis in elderly patients (>65 years old)

HLA-DR4-positive AlH (n = 22)

HLA-DR4-negative AIH (n = 27)

P-value

Discrete traits

N (%)

N (%)

 Sex

0.084

  Male

3 (13.6)

0 (0)

  Female

19 (86.4)

27 (100)

 Pattern of disease onset Acute onset

4 (18.2)

11 (40.7)

0.123

 Other autoimmune diseases

4 (18.2)

2 (7.4)

0.388

 Death from liver disease-related causes

2 (9.10

3 (11.1)

1.000

 ANA positivity

22 (100)

24 (88.9)

0.242

 ANA (<40/40/80/<80)

0/1/6/15

3/5/6/13

0.065

 AMA positivity

5 (22.7)

2 (7.4)

0.219

 Splenomegaly

9 (40.9)

8 (30.8)

0.548

 Fibrosis stage (F0-F2/F3-F4)

6/11

16/7

0.053

Continuous traits

Median (Min-Max)

Median (Min-Max)

P-value

 Age (years)

72 (65–86)

73 (66–88)

0.657

 Total bilirubin (mg/dL)

1.1 (0.5–19.0)

1.1 (0.5–33.2)

0.976

 Aspartate aminotransferase (U/L)

188 (58–1177)

290 (20–641)

0.376

 Alanine aminotransferase (U/L)

191 (62–1208)

284 (16–714)

0.330

 Alkaline phosphatase (U/L)

441.5 (239–1145)

443 (170–793)

0.802

 Gamma-glutamyl transpeptidase (IU/L)

130.5 (47–466)

203 (20–587)

0.287

 Prothrombin time (%)

80.5 (30–104.8)

82 (49–114.4)

0.481

 Albumin (g/dL)

3.5 (2.2–4.5)

3.8 (2.2–4.6)

0.190

 Platelets (x 10⁴/pL)

14.85 (9.6–27.7)

15.7 (8.0–28.8)

0.920

 Immunoglobulin G (mg/dL)

2724.5 (1758–5495)

2030 (1243–3157)

<0.0001

 Immunoglobulin M (mg/dL)

215 (62–1330)

98 (47–396)

0.003

 AIH score (except for histology score)

14 (7–17)

13 (7–16)

0.053

 AIH score (including histology score)

19 (12–22)

17 (8–21)

0.037