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Table 2 Clinical features of HLA–DR4–positiveand HLA–DR4–negativeautoimmune hepatitis

From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis

  HLA–DR4–positive AIH (n = 78) HLA-DR4-negative AIH (n = 54) P–value
Discrete traits N (%) N (%)  
 Sex    0.524
  Male 8 (10.3) 3 (5.6)
  Female 70 (89.7) 51 (94.4)
 Pattern of disease onset Acute onset 27 (34.6) 20 (37.0) 0.854
 Other autoimmune diseases 16 (20.5) 7 (13.0) 0.352
 Death from liver disease–related causes 3 (3.8) 5 (9.3) 0.271
 ANA positivity 71 (91.0) 44 (81.5) 0.121
 ANA (<40/40/80/>80) 7/9/18/44 10/8/10/26 0.435
 AMA positivity 9 (11.5) 4 (7.4) 0.558
 Splenomegaly 21 (27.6) 23 (44.2) 0.090
 Fibrosis stage (F0–F2/F3–F4) 38/31 31/16 0.255
Continuous traits Median (Min–Max) Median (Min–Max) P–value
Age (years) 56 (15–86) 65 (9–88) 0.034
 Total bilirubin (mg/dl) 1.1 (0.4–20.4) 1.1 (0.5–33.2) 0.957
 Aspartate aminotransferase (U/L) 203.5 (21–2738) 254.5 (20–1536) 0.930
 Alanine aminotransferase (U/L) 270 (15–2325) 284 (16–2016) 0.779
 Alkaline phosphatase (U/L) 448.5 (213–1145) 459 (131–1463) 0.860
 Gamma–glutamyl transpeptidase (IU/L) 145.5(26–1404) 147.5 (20–679) 0.842
 Prothrombin time (%) 86 (29–130) 82 (3–130) 0.251
 Albumin (g/dL) 3.7 (1.9–4.7) 3.8 (2.2–4.7) 0.239
 Platelets (x 104/nL) 17.7 (8.9–39.6) 17.55 (6.8–31.5) 0.185
Immunoglobulin G (mg/dL) 2582.5 (938–6750) 2074.5 (945–4961) <0.001
Immunoglobulin M (mg/dL) 181 (62–1720) 115 (47–888) 0.007
 AIH score (except for histology score) 14 (6–18) 13 (7–17) 0.117
 AIH score (including histology score) 18 (9–22) 17 (8–22) 0.450
  1. Bold-faced type shows statistically significant difference