Skip to main content

Table 2 Clinical features of HLA–DR4–positiveand HLA–DR4–negativeautoimmune hepatitis

From: Evaluation of the role of HLA-DR antigens in Japanese type 1 autoimmune hepatitis

 

HLA–DR4–positive AIH (n = 78)

HLA-DR4-negative AIH (n = 54)

P–value

Discrete traits

N (%)

N (%)

 

 Sex

  

0.524

  Male

8 (10.3)

3 (5.6)

  Female

70 (89.7)

51 (94.4)

 Pattern of disease onset Acute onset

27 (34.6)

20 (37.0)

0.854

 Other autoimmune diseases

16 (20.5)

7 (13.0)

0.352

 Death from liver disease–related causes

3 (3.8)

5 (9.3)

0.271

 ANA positivity

71 (91.0)

44 (81.5)

0.121

 ANA (<40/40/80/>80)

7/9/18/44

10/8/10/26

0.435

 AMA positivity

9 (11.5)

4 (7.4)

0.558

 Splenomegaly

21 (27.6)

23 (44.2)

0.090

 Fibrosis stage (F0–F2/F3–F4)

38/31

31/16

0.255

Continuous traits

Median (Min–Max)

Median (Min–Max)

P–value

 Age (years)

56 (15–86)

65 (9–88)

0.034

 Total bilirubin (mg/dl)

1.1 (0.4–20.4)

1.1 (0.5–33.2)

0.957

 Aspartate aminotransferase (U/L)

203.5 (21–2738)

254.5 (20–1536)

0.930

 Alanine aminotransferase (U/L)

270 (15–2325)

284 (16–2016)

0.779

 Alkaline phosphatase (U/L)

448.5 (213–1145)

459 (131–1463)

0.860

 Gamma–glutamyl transpeptidase (IU/L)

145.5(26–1404)

147.5 (20–679)

0.842

 Prothrombin time (%)

86 (29–130)

82 (3–130)

0.251

 Albumin (g/dL)

3.7 (1.9–4.7)

3.8 (2.2–4.7)

0.239

 Platelets (x 104/nL)

17.7 (8.9–39.6)

17.55 (6.8–31.5)

0.185

 Immunoglobulin G (mg/dL)

2582.5 (938–6750)

2074.5 (945–4961)

<0.001

 Immunoglobulin M (mg/dL)

181 (62–1720)

115 (47–888)

0.007

 AIH score (except for histology score)

14 (6–18)

13 (7–17)

0.117

 AIH score (including histology score)

18 (9–22)

17 (8–22)

0.450

  1. Bold-faced type shows statistically significant difference