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Table 2 Assessment of gastroesophageal reflux with and without administration of acotiamide

From: Effects of acotiamide on esophageal motor function and gastroesophageal reflux in healthy volunteers

  24 h   Post prandial (6 h)  
  Control Acotiamide p value Control Acotiamide p value
pH <4 (%) 1.1 [0.5–2.0] 0.6 [0.3–2.4] 0.47 2.0 [0.3–3.3] 2.0 [0.8–2.6] 0.99
Number of reflux episodes
 Total reflux 56.0 [44.0–76.5] 56.0 [25.0–81.5] 0.96 34.0 [23.5–40.5] 34.0 [18.0–48.5] 0.58
 Acid reflux 31.0 [23.0–43.5] 25.0 [15.5–46.0] 0.76 17.0 [8.5–24.5] 15.0 [10.5–26.0] 0.45
Bolus clearance time (s) 14.0 [12.0–15.0] 14.0 [13.0–18.5] 0.11 14.0 [12.5–17.5] 16.0 [14.5–19.0] 0.17
  1. Values are expressed as median. Number of brackets show interquartile range of each pattern