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Table 1 Primary and secondary outcome parameter results (data as estimate ± standard error from the lme model)

From: Volume, distribution and acidity of gastric secretion on and off proton pump inhibitor treatment: a randomized double-blind controlled study in patients with gastro-esophageal reflux disease (GERD) and healthy subjects

Parameter Modality HS GERD
  Placebo PPI Placebo PPI
mean SV [ml] MRI 133 ± 14 73 ± 14* 152 ± 14 66 ± 14*
max SV [ml] MRI 193 ± 17 100 ± 18* 227 ± 18 94 ± 17*
Layer thickness at 60 min [mm] MRI 26 ± 5 7 ± 5* 36 ± 5 9 ± 5*
Layer Volume at 60 min [ml] MRI 79 ± 16 20 ± 16* 117 ± 17 18 ± 17*
Median mingastricph pH-monitoring 1.8 ± 0.3 4.5 ± 0.3* 1.5 ± 0.3 3.8 ± 0.3*
2 h postprandial
t50 [min] MRI 60 ± 6 71 ± 6 62 ± 6 64 ± 6
EGJ exposure time to ≥ 70 % secretion layer Normalized to T50 MRI 0.45 ± 0.2 0.42 ± 0.2 1.18 ± 0.2*** 0.42 ± 0.2**
Eraflux symptoms score Questionnaire 0 ± 0 0 ± 0 33 ± 3 20 ± 3*
  1. * <0.05, ** p < 0.01 different to placebo
  2. *** <0.05, p < 0.01 different to HS
  3. Poisson distributed parameter