TY - JOUR AU - Steingoetter, Andreas AU - Sauter, Matthias AU - Curcic, Jelena AU - Liu, Dian AU - Menne, Dieter AU - Fried, Michael AU - Fox, Mark AU - Schwizer, Werner PY - 2015 DA - 2015/09/02 TI - Volume, distribution and acidity of gastric secretion on and off proton pump inhibitor treatment: a randomized double-blind controlled study in patients with gastro-esophageal reflux disease (GERD) and healthy subjects JO - BMC Gastroenterology SP - 111 VL - 15 IS - 1 AB - Postprandial accumulation of gastric secretions in the proximal stomach above the meal adjacent to the esophagogastric junction (EGJ), referred to as the ‘acid pocket’, has been proposed as a pathophysiological factor in gastro-esophageal reflux disease (GERD) and as a target for GERD treatment. This study assessed the effect of proton pump inhibitor (PPI) therapy on the volume, distribution and acidity of gastric secretions in GERD and healthy subjects (HS). SN - 1471-230X UR - https://doi.org/10.1186/s12876-015-0343-x DO - 10.1186/s12876-015-0343-x ID - Steingoetter2015 ER -