Regulators | Role | State (z-score) | p | Target genes regulated |
---|---|---|---|---|
PDGF | Mitogenic | ↗ (3.41) | 10−16 | ATF3, CNN1, CTGF, CYR61, DUSP1, EGR1, FOS, FOSB, GEM, IL1B, JUN, KLF6, RGS1, SLC2A3, THBS1, ZFP36 |
Jnk | Inflammation | ↗ (2.77) | 10−07 | BIRC3, CTGF, DUSP1, IL1B, JUN, PTGS2, VCAM1, ZFP36 |
ERK | Mitogenic | ↗ (2.62) | 10−09 | CTGF, DUSP1, EGR1, FOS, HBEGF, JUN, MUC5AC, PDK4, PTGS2, THBS1, ZFP36 |
F7 | Coagulation | ↗ (2.40) | 10−07 | CTGF, EGR1, FOS, HBEGF, IL1B, ZFP36 |
TREM1 | Inflammation | ↗ (2.33) | 10−05 | ATF3, CFB, EGR1, GADD45B, GEM, HBEGF, IL1B, PTGS2, RGS1, THBS1 |
C/EBPα | Transcription | ↗ (2.22) | 10−03 | BTG2, CSF3R, CXCR4, PTGS2, S100A9 |
CD40LG | Immunity | ↗ (2.20) | 10−05 | BIRC3, E2F2, HLA-DQA1, HLA-DRB4, IL1B, PTGS2, VCAM1 |
MAP2K1/2 | Mitogenic | ↗ (2.19) | 10−05 | ATF3, CTGF, DUSP1, EGR1, IL1B |
IL1α | Inflammation | ↗ (2.17) | 10−03 | BIRC3, IL1B, PTGS2, S100A9, SERPINA3 |
IFNγ | Inflammation | ↗ (2.16) | 10−03 | ATF3, CXCR4, HLA-A/C/DQB1, IL1B, KLF6, PTGS2, VCAM1 |
NUPR1 | Transcription | ↗ (2.12) | 10−01 | ATF3, BRI3BP, CXCR4, CYR61, HBEGF, KLF6, SIK1, ZFAND2 |
SELPLG | Inflammation | ↗ (2.00) | 10−04 | CLK1, CXCR4, FOS, IL1B |
SMAD4 | Transcription | ↗ (2.00) | 10−02 | CTGF, GADD45B, IRAK3, THBS1 |
P38 MAPK | Inflammation | ↗ (2.00) | 10−06 | ATF3, CD55, CTGF, EGR1, FOS, IL1B, JUN, MUC5AC, PTGS2 |
TLR4 | Inflammation | ↗ (2.00) | 10−05 | ATF3, IL1B, IRAK3, MUC5AC, VCAM1 |
IgG | Immunity | ↘ (−2.24) | 10−03 | DUSP1, IL1B, LDLR, SLC2A3, ZFP36 |
Hdac | Deacetylases | ↘ (−2.57) | 10−07 | ATF3, EGR1, FOS, GADD45B, JUN, KLF6, KLF9 |