Skip to main content

Table 1 Differentially expressed genes in the intestine of insulin-resistant compared to insulin-sensitive subjects

From: Altered intestinal functions and increased local inflammation in insulin-resistant obese subjects: a gene-expression profile analysis

Function Genes   Fold change
Intestinal peptides GIP Glucose inhibitory peptide −1.72
GKN1 Gastrokine 1 −1.54
GKN2 Gastrokine 2 −1.51
VIP Vasoactive intestinal polypeptide 1.30
Inflammation and oxidative stress PTGS2 Prostaglandin-endoperoxide synthase – COX-2 1.20
DUSD1 Dual specificity phosphatase 1 1.37
S100A8 S100 calcium binding protein A8 1.59
S100A9 S100 calcium binding protein A9 1.51
IL1B Interleukin 1 beta 1.21
GPX8 Glutathione peroxidase 8 1.21
FOS Cellular oncogene c-Fos 1.55
JUN Jun proto-oncogene 1.32
Transporters SLC28A2 Sodium-coupled nucleoside transporter −1.68
SLC2A3 Facilitated glucose transporter 3 1.25
Extracellular matrix MUC5AC Mucin 5 AC −1.58
MUC2 Mucin 2 −1.32
MUC6 Mucin 6 1.21
MMP7 Metalloproteinase 7 1.27
VIL1 Villin 1 −1.22
Digestive functions PGA5 Pepsinogen A −1.97
LCT Lactase 1.76
GLB1 β-galactosidase −1.21
PNLIPRP2 Pancreatic lipase 1.30
PRSS1 Trypsin 1 1.24
ELA3A Elastase 1.25
Immunity GP2 Glycoprotein 2 1.38
HLA-A Major histocompatibility complex class I A 2.63
HLA-C Major histocompatibility complex class I C −1.20
HLA-F Major histocompatibility complex class I F −1.28
HLA-DQA1 Major histocompatibility complex class II DQ alpha 1 1.38
HLA-DQB1 Major histocompatibility complex class II DQ beta 1 1.22
HLA-DRB1 Major histocompatibility complex class II DR beta 1 −1.35
HLA-DRB4 Major histocompatibility complex class II DR beta 4 1.39
Cholesterol homeostasis LDLR Low density lipoprotein receptor 1.30
APOD Apolipoprotein D-III 1.20
APOA1 Apolipoprotein A-I −1.37