Skip to main content

Table 1 Baseline demographic characteristics of the 72 patients with active ulcerative colitis (UC), sub-grouped as responders, partial-responders or non-responders following infliximab (IFX) induction therapy

From: C-reactive protein level at 2 weeks following initiation of infliximab induction therapy predicts outcomes in patients with ulcerative colitis: a 3 year follow-up study

Demography IFX responders (n = 29) IFX partial-responders (n = 24) IFX non-responders (n = 19) P1 Value P2 Value
Male, number (%) 13 (44.8) 14 (58.3) 12 (63.2) 0.4117 0.2500
Age, year 37.5 [30.3–54.4] 37.6 [32.3–45.5] 26.1 [20.2–36.4] 0.9929 0.0315
Duration of UC, year 5.4 [1.8–9.3] 6.3 [2.6–10.4] 2.5 [1.0–6.1] 0.5028 0.0958
Duration (days) of active UC prior to IFX induction 38.0 [26.5–63.0] 107.0 [30.5–178.8] 101.0 [41.0–153.0] 0.0255 0.0072
Dose of infused IFX (mg/kg) 6.2 [5.3–6.7] 5.7 [5.5–6.2] 6.1 [5.3–6.6] 0.4579 0.9411
CRP (mg/dL) 1.17 [0.41–2.74] 1.28 [0.32–2.11] 0.59 [0.26–1.16] 0.8302 0.1739
Albumin (g/dL) 4.4 [4.2–4.6] 4.1 [4.0–4.3] 4.0 [3.7–4.3] 0.0006 0.0022
Haemoglobin (g/dL) 12.3 [11.4–13.6] 12.8 [11.1–13.7] 11.9 [9.9–13.4] 0.9715 0.2820
Partial Mayo Score (0–9) 7 [5–7] 7 [6–8] 7 [5–7] 0.1020 0.8872
UC location, number (%)      
Extensive 23 (79.3) 16 (66.7) 15 (79.0) 0.3579 1.0000
Left-sided 6 (20.7) 8 (33.3) 4 (21.1) 0.3579 1.0000
Corticosteroid dependent, number (%) 18 (62.1) 20 (83.3) 10 (52.6) 0.1274 0.5613
Corticosteroid refractory, number (%) 10 (34.5) 1 (4.2) 9 (47.4) 0.0075 0.5469
Concomitant medication, number (%)      
5-Aminosalicylates 27 (93.1) 23 (95.8) 18 (94.7) 1.0000 1.0000
Corticosteroids 20 (69.0) 14 (58.3) 16 (84.2) 0.5662 0.3157
Azathioprine/ Mercaptopurine 8 (27.6) 6 (25.0) 6 (31.6) 1.0000 1.0000
Previously failed ≥2 immunosuppressant, number (%) 5 (17.2) 1 (4.2) 8 (46.2) 0.2044 0.0959
Smoking status, number (%)      
Currents smoker 2 (6.9) 3 (12.5) 1 (5.3) 0.6486 1.0000
Nonsmoker 24 (82.8) 21 (87.5) 14 (73.7) 0.7153 0.4873
Past smoker 3 (10.3) 0 (0) 4 (21.1) 0.2424 0.4116
  1. Certain values are presented as the median [interquartile range] and compared by Wilcoxon-Mann–Whitney test. Categorical variables are represented as number (%) and compared by the Fisher’s exact test. P1, responder vs partial-responder; P2, responder vs non-responder