Author, year, country | Intervention | Inclusion criteria | Does the study include patients with a pancreatic stent for PEP prophylaxis? | Post-ERCP pancreatitis incidence | Risk Ratio, 95 % CI | |||
---|---|---|---|---|---|---|---|---|
Experimental | Control | |||||||
Events | n | Events | n | |||||
Murray, 2003, Scotland. [14] | 100 mg rectal Diclofenac in recovery area. | High risk patients | Yes | 7 | 110 | 17 | 110 | 0.56 [0.29, 1.05] |
Sotoudenhmanesh, 2007, India. [15] | 100 mg rectal Indomethacin immediately prior to ERCP. | Unselected patients | No | 7 | 221 | 15 | 221 | 0.62 [0.34, 1.16] |
Montaño-Loza, 2007, Mexico. [23] | 100 mg rectal Indomethacin, 2 h before ERCP. | Unselected patients | No | 4 | 75 | 12 | 75 | 0.47 [0.20, 1.12] |
Cheon, 2007, USA. [24] | 50 mg Diclofenac, before and after ERCP by mouth | Unselected patients | Yes | 17 | 105 | 17 | 102 | 0.98 [0.68, 1.42] |
Khoshbaten, 2008, Iran. [22] | 100 mg rectal Diclofenac on arrival to recovery area. | High risk patients | Yes | 2 | 50 | 13 | 50 | 0.24 [0.06, 0.87] |
Senol, 2009, Turkey. [25] | 75 mg diclofenac IM and IV isotonic, after ERCP | Unselected patients | No | 3 | 40 | 7 | 40 | 0.57 [0.21, 1.50] |
Otsuka, 2012, Japan. [26] | 50 mg rectal Diclofenac, 30 min before ERCP. | Unselected patients | No | 2 | 51 | 10 | 53 | 0.31 [0.09, 1.12] |
Elmunzer, 2012, USA. [16] | 100 mg rectal Indomethacin after ERCP. | High risk patients | Yes | 27 | 295 | 52 | 307 | 0.67 [0.49, 0.92] |
Döbrönte, 2012, Hungary. [27] | 100 mg rectal Indomethacin, 10 min before ERCP. | Unselected patients | No | 11 | 130 | 11 | 98 | 0.87 [0.56, 1.34] |
Abu-Safieh Yasser, 2014, Palestine. [28] | 75 mg diclofenac IM, prior the ERCP. | Unselected patients | Yes | 6 | 89 | 12 | 93 | 0.66 [0.34, 1.29] |
Döbrönte, 2014, Hungary. [29] | 100 mg rectal Indomethacin 10–15 min before ERCP. | Unselected patients | No | 20 | 347 | 22 | 318 | 1.10 [0.82, 1.49] |
Present Study, 2015, México. | 100 mg rectal Indomethacin, immediately after ERCP. | High risk Patients | No | 4 | 82 | 17 | 84 | 0.35 [0.14, 0.87] |