Skip to main content
Fig. 4 | BMC Gastroenterology

Fig. 4

From: IGF-1 decreases portal vein endotoxin via regulating intestinal tight junctions and plays a role in attenuating portal hypertension of cirrhotic rats

Fig. 4

a and b occludin level in intestines was decreased during the development of liver cirrhosis in rats, and administration of IGF-1 restored occludin level in intestines in liver cirrhosis to some extent. c and d claudin-1 level in intestines was decreased during the development of liver cirrhosis in rats, and administration of IGF-1 restored claudin-1 level in intestines in liver cirrhosis to some extent. e and f Administration of LPS to Caco-2 cells reduced occludin level, and external administration of IGF-1 attenuated the effect of LPS on occludin expression in Caco-2 cells. g and h Administration of LPS to Caco-2 cells reduced claudin-1 level, and external administration of IGF-1 attenuated the effect of LPS on claudin-1 expression in Caco-2 cells. Data were shown with the mean ± SD. **P <0.001 vs. control group, ## P <0.001 vs. CCL4 group or LPS group

Back to article page