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Table 4 Treatment details, viremia and genotypic resistance in HIV/HBV co-infected patients with a delayed response to TDF treatment

From: HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons

Case HBV genotype HBV drug TDF start date weeks on TDF HBV viremia (cp/ml) date analyses genotypic resistance
1 A exposed to LAM    NA no sample available  
   TDF 3-Jan-05   NA no sample available  
     24 4630 21-Jun-05 L180M M204V
     101 NA 13-Dec-06 L180M M204V
     132 NA 15-Jul-07 L180M M204I
2 A + G exposed to LAM    200000 Before TDF No resistance
   TDF 20-May-04   200000 no sample available  
     125 99 10-Oct-06 No resistance
3 A + G exposed to LAM    NA no sample available  
   TDF 18-Apr-05   920 no sample available  
     116 1520 9-Jul-07 No resistance
4 A exposed to LAM    317′000′000 Before TDF V173L L180M M204V
   TDF 14-Mar-06   186′000′000 no sample available  
     39 273 12-Dec-06 V173L L180M M204V
   TDF + FTC 28-Jun-07 100 29 14-Feb-08 V173L L180M M204V
5 A exposed to LAM    NA no sample available  
   TDF 23-Aug-05   NA no sample available  
     93 207 6-Jun-07 No resistance
6 A + G exposed to LAM    100′000′000 Before TDF No resistance
   TDF 18-Jan-06   1′008′000 no sample available  
7 A exposed to LAM    793′000′000 Before TDF V173L L180M M204I
   TDF + FTC 28-Apr-06   NA no sample available  
     47 240 20-Mar-07 V173L L180M M204V
     73 NA 19-Sep-07 V173L L180M M204V
8 A exposed to LAM    11′000′000 Before TDF No resistance
   TDF + FTC 9-Nov-06 28 NA 21-May-07 V173L L180M M204V
     66 913 12-Feb-08 L180M M204V
9 A + G exposed to LAM    NA Before TDF No resistance
   TDF 25-Sep-06   9′000′000 no sample available  
     43 55 23-Jul-07 No resistance
10 A exposed to LAM    764′690′000 Before TDF No resistance
   TDF 30-Mar-07   38′291 no sample available  
     37 252 17-Dec-07  
11 A + G exposed to LAM    1′100′000′000 Before TDF No resistance
   TDF + FTC 2-Feb-07   727′000 no sample available  
     36 128′000 9-Oct-07 No resistance
12 A exposed to LAM    75 Before TDF No resistance
   TDF 5-Feb-07   49 no sample available  
     28 NA 20-Aug-07