Table 4 Treatment details, viremia and genotypic resistance in HIV/HBV co-infected patients with a delayed response to TDF treatment
From: HBV genotypes and response to tenofovir disoproxil fumarate in HIV/HBV-coinfected persons
Case | HBV genotype | HBV drug | TDF start date | weeks on TDF | HBV viremia (cp/ml) | date analyses | genotypic resistance |
|---|---|---|---|---|---|---|---|
1 | A | exposed to LAM | Â | Â | NA | no sample available | Â |
| Â | Â | TDF | 3-Jan-05 | Â | NA | no sample available | Â |
| Â | Â | Â | Â | 24 | 4630 | 21-Jun-05 | L180M M204V |
| Â | Â | Â | Â | 101 | NA | 13-Dec-06 | L180M M204V |
| Â | Â | Â | Â | 132 | NA | 15-Jul-07 | L180M M204I |
2 | A + G | exposed to LAM |  |  | 200000 | Before TDF | No resistance |
| Â | Â | TDF | 20-May-04 | Â | 200000 | no sample available | Â |
| Â | Â | Â | Â | 125 | 99 | 10-Oct-06 | No resistance |
3 | A + G | exposed to LAM |  |  | NA | no sample available |  |
| Â | Â | TDF | 18-Apr-05 | Â | 920 | no sample available | Â |
| Â | Â | Â | Â | 116 | 1520 | 9-Jul-07 | No resistance |
4 | A | exposed to LAM |  |  | 317′000′000 | Before TDF | V173L L180M M204V |
|  |  | TDF | 14-Mar-06 |  | 186′000′000 | no sample available |  |
| Â | Â | Â | Â | 39 | 273 | 12-Dec-06 | V173L L180M M204V |
|  |  | TDF + FTC | 28-Jun-07 | 100 | 29 | 14-Feb-08 | V173L L180M M204V |
5 | A | exposed to LAM | Â | Â | NA | no sample available | Â |
| Â | Â | TDF | 23-Aug-05 | Â | NA | no sample available | Â |
| Â | Â | Â | Â | 93 | 207 | 6-Jun-07 | No resistance |
6 | A + G | exposed to LAM |  |  | 100′000′000 | Before TDF | No resistance |
|  |  | TDF | 18-Jan-06 |  | 1′008′000 | no sample available |  |
7 | A | exposed to LAM |  |  | 793′000′000 | Before TDF | V173L L180M M204I |
|  |  | TDF + FTC | 28-Apr-06 |  | NA | no sample available |  |
| Â | Â | Â | Â | 47 | 240 | 20-Mar-07 | V173L L180M M204V |
| Â | Â | Â | Â | 73 | NA | 19-Sep-07 | V173L L180M M204V |
8 | A | exposed to LAM |  |  | 11′000′000 | Before TDF | No resistance |
|  |  | TDF + FTC | 9-Nov-06 | 28 | NA | 21-May-07 | V173L L180M M204V |
| Â | Â | Â | Â | 66 | 913 | 12-Feb-08 | L180M M204V |
9 | A + G | exposed to LAM |  |  | NA | Before TDF | No resistance |
|  |  | TDF | 25-Sep-06 |  | 9′000′000 | no sample available |  |
| Â | Â | Â | Â | 43 | 55 | 23-Jul-07 | No resistance |
10 | A | exposed to LAM |  |  | 764′690′000 | Before TDF | No resistance |
|  |  | TDF | 30-Mar-07 |  | 38′291 | no sample available |  |
| Â | Â | Â | Â | 37 | 252 | 17-Dec-07 | Â |
11 | A + G | exposed to LAM |  |  | 1′100′000′000 | Before TDF | No resistance |
|  |  | TDF + FTC | 2-Feb-07 |  | 727′000 | no sample available |  |
|  |  |  |  | 36 | 128′000 | 9-Oct-07 | No resistance |
12 | A | exposed to LAM | Â | Â | 75 | Before TDF | No resistance |
| Â | Â | TDF | 5-Feb-07 | Â | 49 | no sample available | Â |
| Â | Â | Â | Â | 28 | NA | 20-Aug-07 | Â |