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Table 3 Serum levels of osteopontin (OPN) in cirrhotic patients with and without HCC, and the relation to clinical features (Child Pugh class and BCLC stage)

From: Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening

OPN (ng/mL)

Group I

Group II

p-value

(Cirrhosis)

(Cirrhosis and HCC)

 

923.80 (193.80-2786.20)

946.30 (337.10-3583.00)

0.826*

Child-Pugh class

  

<0.001**

A

534.95 (193.80-1778.60)

742.30 (337.10-2593.80)

B

1051.85 (384.20-2786.20)

1017.80 (502.40-2775.10)

C

1549.70 (838.40-2734.00)

1430.15 (844.00-3583.00)

BCLC Stagea

  

0.025**

0

 

434.25 (394.40-474.10)

A

 

844.00 (393.20-2775.10)

B

 

742.30 (337.10-2472.00)

C

 

1754.70 (363.80-2593.80)

D

 

1609.75 (946.30-3583.00)

  1. *p-value by Mann–Whitney U test for comparison of plasma OPN between two group
  2. **p-value by Kruskal-Wallis test for comparison of serum OPN across Child-Pugh classes and BCLC stages
  3. aBarcelona Clinic Liver Cancer