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Table 3 Serum levels of osteopontin (OPN) in cirrhotic patients with and without HCC, and the relation to clinical features (Child Pugh class and BCLC stage)

From: Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening

OPN (ng/mL) Group I Group II p-value
(Cirrhosis) (Cirrhosis and HCC)
  923.80 (193.80-2786.20) 946.30 (337.10-3583.00) 0.826*
Child-Pugh class    <0.001**
A 534.95 (193.80-1778.60) 742.30 (337.10-2593.80)
B 1051.85 (384.20-2786.20) 1017.80 (502.40-2775.10)
C 1549.70 (838.40-2734.00) 1430.15 (844.00-3583.00)
BCLC Stagea    0.025**
0   434.25 (394.40-474.10)
A   844.00 (393.20-2775.10)
B   742.30 (337.10-2472.00)
C   1754.70 (363.80-2593.80)
D   1609.75 (946.30-3583.00)
  1. *p-value by Mann–Whitney U test for comparison of plasma OPN between two group
  2. **p-value by Kruskal-Wallis test for comparison of serum OPN across Child-Pugh classes and BCLC stages
  3. aBarcelona Clinic Liver Cancer