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Table 2 Serum levels of alpha-fetoprotein (AFP) in cirrhotic patients with and without HCC, and the relation to clinical features (Child-Pugh class and BCLC stage)

From: Plasma osteopontin is a biomarker for the severity of alcoholic liver cirrhosis, not for hepatocellular carcinoma screening

AFP (ng/mL) Group I Group II p-value
(Cirrhosis) (Cirrhosis and HCC)
  3.00 (0.90-17.00) 11.00 (1.30-431272.00) <0.001*
Child-Pugh class    0.627 **
A 2.50 (1.10-13.00) 10.00 (1.30-2159.00)
B 3.40 (1.10-5.60) 14.00 (1.60-431272.00)
C 3.10 (0.90-17.00) 12.45 (1.40-8251.00)
BCLC Stage a    0.007 **
0   6.15 (5.90-6.40)
A   3.20 (1.30-242.00)
B   31.00 (2.80-431272.00)
C   225.00 (8.70-7392.00)
D   255.00 (3.30-8251.00)
  1. *p - Value by Mann–Whitney U test for comparison of serum AFP between two groups
  2. **p - Value by Kruskal-Wallis test for comparison of serum AFP across Child-Pugh classes and BCLC stages
  3. aBarcelona Clinic Liver Cancer