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Table 5 Comparison of gallstone composition of cholesterol, proportions of squalene and non-cholesterol sterols and total bile acids in black pigment stones (n = 26) and cholesterol stones (n = 20) between pediatric patients and adult controls (n = 187)

From: Relation of cholesterol metabolism to pediatric gallstone disease: a retrospective controlled study

 

Black pigment stones

Cholesterol stones

P

Children

Adult controls

Children

Adult controls

n = 26

n = 9

n = 20

n = 178

 

Cholesterol

2 ± 2†

3 ± 1

84 ± 2

83 ± 1

<0.001

Squalene

291 ± 71†

-

9 ± 1

-

0.001

Lanosterol

483 ± 21*†

245 ± 45

17 ± 24*

4 ± 1

<0.001

Cholestenol

387 ± 54

118 ± 31

378 ± 61

215 ± 8

<0.001

Lathosterol

956 ± 136†

990 ± 181

2073 ± 155

1915 ± 46

<0.001

Desmosterol

150 ± 769*

48 ± 12

168 ± 876*

60 ± 2

<0.001

Cholestanol

1233 ± 76*

480 ± 68

930 ± 87*

629 ± 22

<0.001

Campesterol

1046 ± 52*

311 ± 60

728 ± 59*

215 ± 8

<0.001

Sitosterol

1343 ± 269*†

389 ± 14

227 ± 307

137 ± 4

<0.001

Stigmasterol

209 ± 64†

-

16 ± 73

-

<0.001

Avenasterol

323 ± 31†

-

94 ± 36

-

<0.001

Bile acids

7.5 ± 1.2*†

3.8 ± 1.0

1.9 ± 0.5

0.7 ± 0.1

<0.001

  1. Values are mean ± SEM. Cholesterol and bile acids mg/100 mg of stone. Squalene and non-cholesterol sterols 100 x mmol/mol of cholesterol
  2. *p < 0.05 compared to the respective value in adults
  3. †p < 0.05 compared to the cholesterol stones
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BMC Gastroenterology

ISSN: 1471-230X

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