Skip to main content

Table 5 Comparison of gallstone composition of cholesterol, proportions of squalene and non-cholesterol sterols and total bile acids in black pigment stones (n = 26) and cholesterol stones (n = 20) between pediatric patients and adult controls (n = 187)

From: Relation of cholesterol metabolism to pediatric gallstone disease: a retrospective controlled study

  Black pigment stones Cholesterol stones P
Children Adult controls Children Adult controls
n = 26 n = 9 n = 20 n = 178  
Cholesterol 2 ± 2 3 ± 1 84 ± 2 83 ± 1 <0.001
Squalene 291 ± 71 - 9 ± 1 - 0.001
Lanosterol 483 ± 21* 245 ± 45 17 ± 24* 4 ± 1 <0.001
Cholestenol 387 ± 54 118 ± 31 378 ± 61 215 ± 8 <0.001
Lathosterol 956 ± 136 990 ± 181 2073 ± 155 1915 ± 46 <0.001
Desmosterol 150 ± 769* 48 ± 12 168 ± 876* 60 ± 2 <0.001
Cholestanol 1233 ± 76* 480 ± 68 930 ± 87* 629 ± 22 <0.001
Campesterol 1046 ± 52* 311 ± 60 728 ± 59* 215 ± 8 <0.001
Sitosterol 1343 ± 269* 389 ± 14 227 ± 307 137 ± 4 <0.001
Stigmasterol 209 ± 64 - 16 ± 73 - <0.001
Avenasterol 323 ± 31 - 94 ± 36 - <0.001
Bile acids 7.5 ± 1.2* 3.8 ± 1.0 1.9 ± 0.5 0.7 ± 0.1 <0.001
  1. Values are mean ± SEM. Cholesterol and bile acids mg/100 mg of stone. Squalene and non-cholesterol sterols 100 x mmol/mol of cholesterol
  2. *p < 0.05 compared to the respective value in adults
  3. p < 0.05 compared to the cholesterol stones