Table 1 Patient characteristics
From: A case series in patients with enteropathy and granulomatous diseases
Patient | A | B | C |
|---|---|---|---|
Major complaints | Sicca syndrome, arthralgias, chronic diarrhoea, weight loss | Dyspnoea on exertion, chronic diarrhoea, weight loss, gait abnormalities | Chronic diarrhoea since childhood, weight loss, arthralgias |
Malabsorptive syndrome | |||
Age at dx | 33 years | 34 years | 35 years |
Duodenal histology | Total villous atrophy | Total villous atrophy, crypt hyperplasia, intraepithelial lymphocytosis | Total villous atrophy, crypt hyperplasia |
Serology | Tg-IgA positive | Tg-IgA repeatedly negative, AIE-75 antibodies elevated | Gliadin-IgA/IgG elevated |
Response to GFD | Temporary improvement of symptoms, normalization of histologic and serologic findings | No improvement of symptoms or histologic findings | Temporary improvement of symptoms, normalization of histologic and serologic findings |
Currently on GFD | Yes | No | Yes |
Granulomatous disease | |||
Age at dx | 36 years | 22 years | 35 years |
Disease manifestations | Pulmonary disease | Pulmonary disease, abdominal lymphadenopathy | Erythema nodosum, abdominal lymphadenopathy |
Histologic findings | Bronchial epithelioid-cell granulomas | Bronchial and abdominal epithelioid-cell granulomas | Abdominal epithelioid-cell granulomas |
Other diagnoses | Sjögren’s syndrome, collagenous colitis | Warm antibody hemolytic anaemia, autoimmune hepatitis, CIDP, progressive spastic paraparesis |