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Table 5 Univariate and multivariate analysis of potential risk factors for mortality with peptic ulcer bleeding after endoscopic treatment at different clinical stages of cirrhotic patients (subgroup analysis)

From: Predicting risk factors for rebleeding, infections, mortality following peptic ulcer bleeding in patients with cirrhosis and the impact of antibiotics prophylaxis at different clinical stages of the disease

Variable

Compensated liver cirrhosis (N = 130)

Decompensated liver cirrhosis (N = 105)

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

p-value

Hazard ratio (95 % CI)

p-value

p-value

Hazard ratio (95 % CI)

p-value

Age

0.753

  

0.115

  

Male gender

0.140

  

0.351

  

Etiology of liver cirrhosis

      

  Alcoholic

0.136

  

0.639

  

  Viral hepatitis

0.281

  

0.422

  

  Cryptogenic

0.644

  

0.482

  

Rockall score

0.014

1.633 (1.103–2.417)

0.014

0.001

1.623 (1.204–2.187)

0.001

MELD score

0.713

  

0.151

  

Child-Pugh score

0.236

  

0.013

1.088 (0.855–1.384)

0.492

Other comorbidities

      

  Diabetes mellitus

0.394

  

0.477

  

  Hypertension

0.352

  

0.831

  

  CVD

0.729

  

0.195

  

  Stroke

0.168

  

0.450

  

  ESRD

0.986

  

0.128

  

  COPD

0.584

  

0.157

  

Use of NSAID or aspirin

0.386

  

0.128

  

Smoking

0.629

  

0.975

  

Active alcoholism

0.533

  

0.177

  

WBC (109/l)

0.428

  

0.880

  

Hb (g/dl)

0.921

  

0.463

  

PLT (109/l)

0.796

  

0.375

  

PT (second)

0.898

  

0.597

  

Creatinine (mg/dl)

0.766

  

0.869

  

Albumin (g/l)

0.517

  

0.955

  

Total bilirubin

0.450

  

0.167

  

Blood units transfused

0.794

  

0.309

  

Hypovolemic shock on admission

0.396

  

0.751

  

High risk bleeding stigmata at ulcer base

0.593

  

0.676

  

Time (h), bleeding to endoscopic treatment

0.734

  

0.085

  

Combined treatment of endoscopic hemostasis

0.229

  

0.538

  

Bacterial infection

0.327

  

0.224

  

Recurrent bleeding

0.043

3.684 (1.040–13.05)

0.044

0.096

  

Antibiotic prophylaxis

0.830

  

0.042

0.395 (0.173–0.899)

0.027

  1. Abbreviations: CI, confidence interval; COPD, chronic obstructive pulmonary disease; CVD, Cardiovascular disease; ESRD, end-stage renal disease; MELD, Model for End-Stage Liver Disease; NSAID, nonsteroidal anti-inflammatory drug; WBC, white blood cells; Hb, hemoglobin; PLT, platelet count; PT, prothrombin time